Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Overactive Bladder, Urge Incontinence |
Dose: Immediate release – 2 mg Frequency: every 12 hours Note: by mouth; reduce to 1 mg twice daily if needed to reduce side effects |
|
Indication: Overactive Bladder, Urge Incontinence |
Dose: Extended release – 2-4 mg Frequency: once daily Note: by mouth |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: less than 18 years |
Dose: Not recommended Note: Not recommended |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment CrCl 10-30 mL/min |
Dose: Tablet (immediate release) – 1 mg Frequency: every 12 hours Note: Not to exceed 1 mg by mouth every 12 hours |
|
Condition: Renal impairment CrCl 10-30 mL/min |
Dose: Tablet (extended release) – 2 mg Frequency: once daily Note: Not to exceed 2 mg by mouth once daily |
Administration
- Take as directed
- Follow prescribed schedule
Side Effect
- Dry mouth (40%)
- Blurred vision
- Constipation
- Dizziness
- Drowsiness
- Dyspepsia
- Headache
- Xerophthalmia
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
CYP3A4 inhibitors (e.g. Macrolide Antibiotics (Erythromycin, Clarithromycin, Azithromycin), Azole Antifungals (Fluconazole, Itraconazole, Ketoconazole, Voriconazole, Posaconazole), protease inhibitors, ciclosporin, vinblastine)
|
Increased risk of overdosage
|
|
Drugs that prolong the QT interval (e.g. class Ia and class III Antiarrhythmics (Amiodarone, Flecainide, Propafenone, Quinidine, Disopyramide, Procainamide))
|
Increased risk of torsade de pointes
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Urinary/Gastric Retention
|
Can worsen retention
|
|
Myasthenia Gravis
|
Can worsen muscle weakness
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place. Protect from light. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.