Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Anti-inflammatory or immunosuppressive Age: Adult Condition: Small joints |
Dose: Intra-articular Injection – 4-10 mg Frequency: May be repeated every 1-5 weeks depending on patient's response Note: As methylprednisolone acetate |
|
Indication: Anti-inflammatory or immunosuppressive Age: Adult Condition: Medium joints |
Dose: Intra-articular Injection – 10-40 mg Frequency: May be repeated every 1-5 weeks depending on patient's response Note: As methylprednisolone acetate |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Adrenogenital syndrome |
Dose: Intramuscular Injection – 40 mg Frequency: Every two weeks |
|
Indication: Inflammation or Immunosuppression |
Dose: Intramuscular Injection – 0.11 to 1.6 mg/kg/day |
Administration
- For injection use only
- Must be administered by healthcare professional
Side Effect
- Allergic or hypersensitivity reactions
- anaphylactoid reaction
- anaphylaxis
- angioedema
- Bradycardia
- cardiac arrest
- cardiac arrhythmias
- cardiac enlargement
- circulatory collapse
- congestive heart failure
- fat embolism
- hypertension
- hypertrophic cardiomyopthy in premature infants
- myocardial rupture following recent mycocardial infarction
- pulmonary edema
- syncope
- tachycardia
- thromboembolism
- thrombophlebitis
- vasculitis
- Acne
- allergic dermatitis
- cutaneous and subcutaneous atrophy
- dry scaly skin
- ecchymoses and petechiae
- edema
- erythema
- hyperpigmentation
- hypopigmentation
- impaired wound healing
- increase sweating
- rash
- sterile abscess
- striae
- suppressed reactions to skin tests
- thin fragile skin
- thinning scalp hair
- urticaria
- Decreased carbohydrate and glucose tolerance
- development of cushingoid state
- glycosuria
- hirsutism
- hypertrichosis
- increased requirements for insulin or oral hypoglycemic agents in diabetes
- manifestations of latent diabetes mellitus
- menstrual irregularities
- secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery or illness)
- suppression of growth in pediatric patients
- Congestive heart failure in susceptible patients
- Fluid retention
- hypokalemic alkalosis
- potassium loss
- sodium retention
- Abdominal distention
- bowel/bladder dysfunction (after intrathecal administration)
- elevation in serum liver enzymes levels (usually reversible upon discontinuation)
- hepatomegaly
- increased appetite
- nausea
- pancreatitis
- peptic ulcer with possible subsequent perforation and hemorrhage
- perforation of the small and large intestine (particularly in patients with inflammatory bowel disease)
- ulcerative esophagitis
- Aseptic necrosis of femoral and humeral heads
- calcinosis (following intra-articular or intra-lesional use)
- Charcot-like arthropathy
- loss of muscle mass
- muscle weakness
- osteoporosis
- pathologic fracture of long bones
- postinjection flare (following intra-articular use)
- steroid myopathy
- tendon rupture
- vertebral compression fractures
- Convulsions
- depression
- emotional instability
- euphoria
- headache
- increased intracranial pressure with papilledema (pseudotumor cerebri) usually following discontinuation of treatment
- insomnia
- mood swings
- neuritis
- neuropathy
- paresthesia
- personality changes
- psychic disorders
- vertigo
- Exophthalmoses
- glaucoma
- increased intraocular pressure
- posterior subcapsular cataracts
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Same as Methylprednisolone
|
Same effects as Methylprednisolone
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Known Hypersensitivity
|
Risk of severe allergic reactions
|
|
Idiopathic Thrombocytopenic Purpura
|
Risk of bleeding complications
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 20-25° C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.