Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Depression Age: Adult |
Dose: Conventional tablet – 75 mg/day Frequency: in 2 or 3 divided doses Note: may increase in increments of up to 75 mg/day at intervals of 4 days or more. Maximum: 375 mg/day. |
|
Indication: Depression Age: Adult |
Dose: Extended-release – 37.5-75 mg Frequency: once daily Note: in patients initiated at 37.5 mg once daily, may increase to 75 mg once daily after 4-7 days; dose may then be increased in increments of up to 75 mg/day at intervals of 4 days or more. Maximum: 225 mg/day. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Attention Deficit Disorder |
Dose: by mouth (oral) – 12.5 mg/day initially Note: increase by 12.5 mg/week; not to exceed 50 mg/day divided twice daily |
|
Indication: Attention Deficit Disorder |
Dose: by mouth (oral) – 12.5 mg/day initially Note: increase by 25 mg/week; not to exceed 75 mg/day divided three times daily |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: glomerular filtration rate less than 30 mL/min and patient requiring haemodialysis |
Dose: Reduce dose by 50% Note: Renal impairment: glomerular filtration rate less than 30 mL/min and patient requiring haemodialysis: Reduce dose by 50% |
Administration
- Take with food
- Take at same time each day
Side Effect
- Headache (25-38%)
- Nausea (21-58%)
- Insomnia (15-24%)
- Asthenia (16-20%)
- Dizziness (11-24%)
- Ejaculation disorder (2-19%)
- Somnolence (12-26%)
- Dry mouth (12-22%)
- Diaphoresis (7-19%)
- Anorexia (15-17%)
- Nervousness (17-26%)
- Anorgasmia (5-13%)
- Weight loss (1-6%)
- Abnormal vision (4-6%)
- Hypertension (2-5%)
- Impotence (4-6%)
- Paresthesia (2-3%)
- )
- Vasodilation (2-6%)
- Vomiting (3-8%)
- Weight gain (2%)
- Flatulence (3-4%)
- Pruritus (1%)
- Yawning (3-8%)
- Dyspepsia (5-7%)
- Twitching (1-3%)
- Mydriasis (2%)
- Angioedema
- Agranulocytosis
- Anemia
- Anuria
- Aneurism
- Bacteremia
- Myasthenia
- Syncope
- Suicide ideation/attempt
- Blood dyscrasias
- Stevens-Johnson syndrome
- hepatitis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
TCA, SSRI, SNRI, lithium, sibutramine, tramadol
|
Increased risk of serotonin syndrome
|
|
CYP3A4 inhibitors (e.g. ketoconazole, atazanavir, clarithromycin)
|
May increase serum levels
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Uncontrolled Hypertension
|
Risk of dangerous blood pressure elevation
|
|
High Risk of Serious Ventricular Arrhythmia
|
Risk of life-threatening heart rhythm problems
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 20-25° C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.