Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Oral Prophylaxis of nausea and vomiting Age: Adult Condition: As maleate |
Dose: Oral – 5-10 mg Frequency: twice daily or three times daily |
|
Indication: Nausea and vomiting Age: Adult Condition: As maleate |
Dose: Oral – 20 mg Note: Further doses are given if needed |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Psychoses Age: Child: 1-5 years |
Dose: Oral – 1.25-2.5 mg Frequency: May be given up to three times daily, if necessary |
|
Indication: Psychoses Age: Child: 5-12 years |
Dose: Oral – 2.5-5 mg Frequency: May be given up to three times daily, if necessary |
Administration
- Can be taken with or without food
- Take at regular intervals
Side Effect
- Insomnia
- Restlessness
- Dizziness
- Anxiety
- Euphoria
- Agitation
- Depression
- Weakness
- Headache
- Cerebral edema
- Poikilothermia
- Tachycardia
- ECG changes
- Anorexia
- Dyspepsia
- Constipation
- Diarrhea
- Ileus
- Blood dyscrasia
- Galactorrhea
- Gynecomastia
- Ejaculatory disorder
- Lens opacities (with prolonged use)
- Photosensitivity
- Pruritus
- Akathisia
- Sedation
- Anticholinergic effects
- Weight gain
- Oligomenorrhea or amenorrhea
- Erectile dysfunction
- Extrapyramidal symptoms (muscle stiffness, dystonia, parkinsonism, tardive dyskinesia)
- Neuroleptic malignant syndrome (infrequent but serious)
- Seizure
- Decreased gag reflex
- Confusion
- Hypotension
- Hypertension
- Leukopenia
- Agranulocytosis
- Cholestatic jaundice
- Photosensitivity reaction
- Priapism
- Hepatotoxicity
- Bone-marrow suppression
- Cardiac arrhythmias or aspiration
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Antihistamines (Diphenhydramine, Loratadine, Levocetirizine, Cetirizine, Fexofenadine, Hydroxyzine, Bilastin), Tricyclic Antidepressants (Fluoxetine, Sertraline, Paroxetine, Citalopram, Escitalopram, Venlafaxine, Duloxetine), Drugs used in parkinsonism
|
Additive anticholinergic effects
|
|
Guanethidine, Other adrenergic neurone blockers
|
May reduce antihypertensive effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
CNS Depression
|
Can worsen drowsiness
|
|
Bone Marrow Depression
|
Can worsen blood cell production
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store below 30°C.Protect from light and moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.