Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Primary herpes simplex infections Age: Adult |
Dose: Oral – 200 mg Frequency: 5 times daily every 4 hours (omitting the night time dose) Duration: 5-10 days |
|
Indication: Primary herpes simplex infections Age: Adult Condition: Severely immunocompromised patients and those with impaired absorption |
Dose: Oral – 400 mg Frequency: 5 times daily Duration: 5 days |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Primary herpes simplex infections Age: greater than 2 years |
Dose: Oral – 200 mg Frequency: 5 times daily every 4 hours (omitting the night time dose) Duration: 5-10 days |
|
Indication: Primary herpes simplex infections Age: greater than 2 years Condition: severely immuno compromised patients and those with impaired absorption |
Dose: Oral – 400 mg Frequency: 5 times daily Duration: 5 days |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Adult Condition: Creatinine Clearance less than 10 mL/min/1.73 m² |
Dose: by mouth (oral) – 200 mg Frequency: every 12 hours Note: Based on normal dosage of 200 mg every 4 hours or 400 mg every 12 hours |
|
Age: Adult Condition: Creatinine Clearance 10-25 mL/min/1.73 m² |
Dose: by mouth (oral) – 800 mg Frequency: every 8 hours Note: Based on normal dosage of 800 mg every 4 hours |
Administration
- Can be taken with or without food
- Take with water
Side Effect
- Malaise (Less than 12%)
- Nausea (2-5%)
- Vomiting (Less than 3%)
- Diarrhea (2-3%)
- Headache (2%)
- pain
- Aggression/confusion
- Agitation
- Alopecia
- Anaphylaxis
- Anemia
- Angioedema
- Anorexia
- Ataxia
- Coma
- Disseminated intravascular coagulation (DIC)
- Dizziness
- Fatigue
- Occasionally neurotoxicity after IV use Lethargy
- confusion
- agitation
- tremors
- seizures
- coma
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Probenecid, Cimetidine, Mycophenolate mofetil
|
May increase the plasma concentration of aciclovir
|
|
Ciclosporin, Tacrolimus
|
Increased nephrotoxic effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Should be stored below 25°C. It should be protected from light and moisture.Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.