Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Adjuvant treatment of Stage III colon cancer Age: Adult Condition: Single agent |
Dose: Oral – 1,250 mg/m2 Frequency: twice daily Duration: first 14 days of each 21-day cycle for a maximum of 8 cycles |
|
Indication: Adjuvant treatment of Stage III colon cancer Age: Adult Condition: In combination with oxaliplatin-containing regimens |
Dose: Oral – 1,000 mg/m2 Frequency: twice daily Duration: first 14 days of each 21-day cycle for a maximum of 8 cycles Note: In combination with oxaliplatin 130 mg/m2 administered intravenously on day 1 of each cycle |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Mild renal impairment (Creatinine Clearance 51-80 mL/minute) |
Dose: Not mentioned Note: No dose reduction necessary |
|
Condition: Moderate renal impairment (Creatinine Clearance 30-50 mL/minute) |
Dose: Not mentioned – 950 mg/m2 Frequency: twice daily Note: Reduce dose to 75% of starting dose (ie, from 1250 mg/m2 to 950 mg/m2 twice daily) |
Administration
- Take with food
- Take within 30 minutes after meal
Side Effect
- Diarrhea
- Nausea
- Anemia
- Lymphopenia
- Hand and foot syndrome
- Edema
- Fatigue
- Fever
- Headache
- Pain
- Paresthesia
- Alopecia
- Dermatitis
- Abdominal pain
- Anorexia
- Appetite decreased
- Constipation
- Dyspepsia
- Stomatitis
- Vomiting
- Neutropenia
- Thrombocytopenia
- Dyspnea
- Bilirubin increased
- Eye irritation
- Chest pain
- Dermatitis
- Pruritus
- Rash
- Dizziness
- Headache
- Weakness
- Dehydration
- Dry mouth
- Dyspepsia
- Taste disturbance
- Back pain
- Cardiotoxicity
- bone-marrow depression and hyperbilirubinaemia
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Antacids containing aluminum and magnesium
|
Drug interaction reported
|
|
Leucovorin, Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban), phenytoin, allopurinol
|
Drug interaction reported
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Renal Impairment
|
Can cause severe toxicity in patients with kidney dysfunction
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Product should be stored at a dry place of controlled room temperature below 30° C and kept out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.