Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Acute Nonlymphocytic Leukemia Condition: Remission induction |
Dose: Intravenous administration – 100-200 mg/square meter/day Duration: 5-10 days Note: Begin second course in 2-4 weeks after initial therapy if necessary |
|
Indication: Acute Nonlymphocytic Leukemia Condition: Remission induction |
Dose: Intravenous administration – 100 mg/square meter Duration: 7 days |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Remission induction in acute non-lymphocytic leukemia Age: Pediatric patients |
Dose: Intravenous – 100 mg/m2/day Frequency: continuous intravenous infusion Duration: 7 days |
|
Indication: Remission induction in acute non-lymphocytic leukemia Age: Pediatric patients |
Dose: Intravenous – 100 mg/m2 Frequency: every 12 hours Duration: 7 days |
Administration
- For hospital use only
- Can be given IV or subcutaneous
Side Effect
- Anorexia
- Nausea
- Vomiting
- Diarrhea
- Oral/anal inflammation
- Thrombophlebitis
- Bleeding
- Myelosuppression
- Rash
- Fever
- Hepatic dysfunction
- Headache
- Neuropathy
- Chest pain
- Pericarditis
- Pneumonia
- Anemia
- Bleeding
- Leukopenia
- Thrombocytopenia
- Kidney disease
- Infectious disease
- Sepsis
- "Cytarabine syndrome" fever
- myalgia
- bone pain
- rash
- conjunctivitis
- malaise
- Skin ulcers
- Cellulitis
- Urinary retention
- Neuritis
- Jaundice
- Anaphylaxis
- Convulsions
- Cerebellar dysfunction
- respiratory distress syndrome
- GI perforation
- bone marrow suppression
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Gentamicin, digoxin, flucytosine
|
May reduce efficacy
|
|
Radiotherapy, other myelotoxic drugs
|
Potentially Fatal: Potentiates bone marrow depression
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
IV/SC: Store between 15-25°C. Intrathecal: Store between 2-8°C. Avoid freezing.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.