Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: DVT & Pulmonary Embolism Prophylaxis |
Dose: Subcutaneous Injection – 5000 units Frequency: every 8 to 12 hours |
|
Indication: DVT & Pulmonary Embolism Prophylaxis |
Dose: Subcutaneous Injection – 7500 units Frequency: every 12 hours |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Venous Thromboembolic Prophylaxis |
Dose: Intravenous – 100-150 units/kg Frequency: once |
|
Indication: Venous Thromboembolic Treatment Age: less than 1 year |
Dose: Intravenous – Loading dose of 75 units/kg, THEN 28 units/kg/hr initial maintenance dose Note: Intravenous infusion |
Administration
- Hospital use only
- Given by IV/injection
Side Effect
- Heparin-induced thrombocytopenia
- possibly delayed (10-30%)
- Mild pain
- Hematoma
- Hemorrhage
- Local irritation
- Erythema
- Injection site ulcer (after deep SC injection)
- Increased liver aminotransferase
- Anaphylaxis
- Immune hypersensitivity reaction
- Osteoporosis (long-term, high-dose use)
- Heparin-induced thrombocytopenia with or without thrombosis
- bleeding
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Platelet aggregation inhibitors, Thrombolytic agents, Salicylates, NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac), Vitamin K antagonists, Dextrans, Activated protein C
|
Enhanced anticoagulant effect
|
|
Glyceryl trinitrate infusion
|
Decreased anticoagulant effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Active Bleeding, Thrombocytopenia
|
Can increase bleeding risk
|
|
Peptic Ulcer Disease
|
Can cause dangerous bleeding
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 20-25° C. Protect from freezing.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.