Question 1

What is this medicine for, and how does it work?

Accepted Answer

This is an anti-cancer medication used in the treatment of leukemia. It's a purine analog that interferes with DNA and RNA synthesis, preventing cancer cell growth. It affects rapidly dividing cancer cells more than normal cells in the body.

Question 2

When and how should this medicine be taken?

Accepted Answer

• Take on an empty stomach • Take 1 hour before or 2 hours after meals • Drink plenty of water • Take at the same time each day

Question 3

When should this medicine not be used?

Accepted Answer

• During pregnancy • During breastfeeding • Severe infections • Known allergy to mercaptopurine

Question 4

What precautions should be taken before using this medicine?

Accepted Answer

• Monitor liver function regularly • Use caution in patients with liver or kidney problems • May increase risk of certain cancers • Check for enzyme deficiency before starting treatment

Question 5

Is it safe to use this medicine during pregnancy?

Accepted Answer

• Not safe during pregnancy • Can cause harm to the fetus • Use effective contraception during treatment

Question 6

Can this medicine be used while breastfeeding?

Accepted Answer

• Monitor liver function regularly • Use caution in patients with liver or kidney problems • May increase risk of certain cancers • Check for enzyme deficiency before starting treatment

Question 7

Is this medicine suitable for children and elderly?

Accepted Answer

• Dosage may need reduction in liver and kidney problems

Question 8

What should be done if a dose is missed?

Accepted Answer

• If you miss a dose, take it as soon as you remember. • However, if it's almost time for your next dose, skip the missed dose. • Never take two doses together. • For once-daily dosing: If you remember on the same day, take the dose. • For twice-daily dosing: If more than 6 hours until your next dose, take the missed dose. • Take your next dose at the regular time. • If you miss multiple doses, contact your doctor.

Question 9

What should be done in case of an overdose?

Accepted Answer

• Symptoms: Vomiting, anemia, leucopenia. • Treatment: Monitor blood counts, supportive care.

Question 10

What should be done if side effects are experienced?

Accepted Answer

• Common side effects: Nausea, vomiting, fatigue, loss of appetite, elevated liver enzymes, rash, diarrhea ** • What to do: Regular blood tests; Report fever/infection; Take on empty stomach; Stay hydrated; Monitor for jaundice; Stop taking the medication and seek medical advice if any severe side effect or unusual symptoms occur.

Question 11

What is Puri-Nethol 50mg used for?

Accepted Answer

Puri-Nethol 50mg (Mercaptopurine) is a pharmaceutical medicine manufactured by Excella, Germany in Bangladesh. It is primarily prescribed for Acute Lymphatic Leukaemia, Crohn's Disease.

Question 12

What is the active generic component of Puri-Nethol?

Accepted Answer

The active ingredient in Puri-Nethol is Mercaptopurine, belonging to the Antimetabolites drug class.

Question 13

What is the retail price of Puri-Nethol 50mg in Bangladesh?

Accepted Answer

The official retail price of Puri-Nethol 50mg (Tablet) is ৳40.76 in Bangladesh (prices may vary slightly by pack size and authorized pharmacy).

Question 14

What is the recommended dosage for Puri-Nethol?

Accepted Answer

Standard adult dosage: by mouth – 2.5 mg/kg or 100-200 mg (once daily). Pediatric dosage: by mouth (oral) – 1.25-2.5 mg/kg (50-75 mg/m²) (once daily). Always consult a registered physician for individualized dosage adjustments based on clinical assessment.

Question 15

Is Puri-Nethol safe during pregnancy and breastfeeding?

Accepted Answer

Puri-Nethol is classified under Pregnancy Category "Not Assigned". Always consult your healthcare provider or OB/GYN before taking this medication during pregnancy or lactation.

Question 16

What are the common side effects of Puri-Nethol?

Accepted Answer

**More than 10%**; Elevated LFT's (15%); **1-10%**; Nausea (10%);Vomiting (10%);Stomatitis (3-10%);Thrombocytopenia (3-10%);Rash (1-3%);Diarrhea (1-3%);Dizziness (1-3%);Alopecia (1-3%);Leukopenia (1-3%); **Frequency Not

Clinical Information	Administration Information
Indication: Acute Lymphatic Leukemia Induction Age: Adult	Dose: by mouth – 2.5 mg/kg or 100-200 mg Frequency: once daily Note: Other agents preferred. May increase by 5 mg/kg/day after 4 weeks. Reduce dose by 75% if concomitant allopurinol administration.
Indication: Acute Lymphatic Leukemia Maintenance Age: Adult	Dose: by mouth – 1.5-2.5 mg/kg Frequency: once daily Note: Reduce dose by 75% if concomitant allopurinol administration.

Clinical Information	Administration Information
Indication: Acute Lymphatic Leukemia Age: Child Condition: Starting dose	Dose: by mouth (oral) – 1.25-2.5 mg/kg (50-75 mg/m²) Frequency: once daily
Indication: Acute Lymphatic Leukemia Age: Child Condition: Maintenance	Dose: by mouth (oral) – 1.5-2.5 mg/kg Frequency: once daily Note: in combination with methotrexate

Drug Name	Risk Factors
Warfarin	Anticoagulant action may be inhibited
Myelosuppressive drugs	Enhanced toxicity

Disease Name	Risk Factors
Prior Resistance to Mercaptopurine/Thioguanine	Leads to treatment failure
Severe Liver Disease	Can worsen liver function

Medicine Overview

Indication

What is this medicine for, and how does it work?

When and how should this medicine be taken?

When should this medicine not be used?

What precautions should be taken before using this medicine?

Is it safe to use this medicine during pregnancy?

Can this medicine be used while breastfeeding?

Is this medicine suitable for children and elderly?

What should be done if a dose is missed?

What should be done in case of an overdose?

What should be done if side effects are experienced?

Adult Dose

Child Dose

Renal Dose

Drug Interaction

Disease Interaction

Pregnancy

Data Sources