Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Growth Hormone Deficiency |
Dose: Subcutaneous Injection – Not to exceed 0.004 mg/kg/day Frequency: once daily Duration: initially for 6 weeks Note: may increase up to 0.016 mg/kg/day maximum |
|
Indication: Growth Hormone Deficiency Condition: Nonweight-based dosing |
Dose: Subcutaneous Injection – 0.2 mg/day (0.15-0.3 mg/day range) Frequency: once daily Note: initially; may increase every 1-2 months by 0.1-0.2 mg/day based on clinical response and/or serum IGF-I levels |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Growth Hormone Deficiency |
Dose: Subcutaneous Injection – 0.024-0.034 mg/kg/day Frequency: 6-7 days/week |
|
Indication: Small for Gestational Age |
Dose: Subcutaneous Injection – Not to exceed 0.067 mg/kg/day Note: Not to exceed 0.067 mg/kg/day |
Administration
- Subcutaneous injection
- Rotate injection sites
Side Effect
- Hypothyroidism
- peripheral oedema
- headache
- muscle and joint pain
- benign intracranial hypertension
- Loss of glycaemic control in diabetics
- New onset Diabetes Mellitus Type 2
- Scoliosis
- Hypoglycemia
- Seizures
- Pancreatitis
- Exacerbation of psoriasis
- Hematuria
- Hematoma
- Leukemia
- Papilledema
- Arthralgia
- Hyperlipidemia
- Otitis media
- Ear disorders
- Respiratory Illness
- Urinary Tract Infection (UTI)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Corticosteroids (Prednisone, Prednisolone, Methylprednisolone, Dexamethasone, Hydrocortisone)
|
High doses may inhibit growth-promoting effects of somatropin
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Acute Critical Illness
|
Can worsen patient condition
|
|
Active Neoplasms
|
May stimulate tumor growth
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 2-8° C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.