Indication: Reversal of Conscious Sedation and General Anesthesia

Dose: Intravenous – 0.2 mg

Frequency: once, then every 1 minute as needed

Note: Administer over 15 seconds. If after 45 seconds no response, administer 0.2 mg again over 1 minute; may repeat at 1 minute intervals; not to exceed 4 doses (1 mg). If resedation occurs, may repeat doses at 20-minute intervals; not to exceed 1 mg/dose or 3 mg/hour.

Indication: Benzodiazepine Overdose

Dose: Intravenous – 0.2 mg

Frequency: once, then every 1 minute as needed

Note: Administer over 15-30 seconds. If no response after 30 seconds, administer 0.3 mg over 30 seconds 1 minute later; if no response, repeat dose of 0.5 mg intravenous over 30 seconds at 1-minute intervals to maximum cumulative dose of 3 mg/hour. In the event of resedation, may repeat dose at 20-minute intervals if needed; not to exceed 1 mg (administered as 0.5 mg/minute) administered at any one time and no more than 3 mg/hour. Rarely patient may require titration up to total dose 5 mg; if no response after 5 minutes, sedation unlikely to be secondary to benzodiazepines.

Indication: Reversal of Benzodiazepine Sedation

Dose: Intravenous – 0.01 mg/kg x1 dose

Note: administered over 15 seconds

Indication: Reversal of Benzodiazepine Sedation

Dose: Intravenous – 0.01 mg/kg

Frequency: every minute

Note: may repeat after 45 seconds; not to exceed 4 doses for a maximum 0.05 mg/kg or 1 mg, whichever is lower

Condition: Renal impairment

Dose: Not studied

Note: Renal impairment has not been studied.