Medicine Overview

Indication

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Adult Dose

Clinical InformationAdministration Information
Indication: Unstable angina and non-Q-wave myocardial infarction
Age: Adult
Dose: Subcutaneous – 120 units/kg
Frequency: every 12 hours
Note: with aspirin
Indication: Deep vein thrombosis prophylaxis in abdominal surgery
Age: Adult
Dose: Subcutaneous – 2,500 units
Frequency: once daily

Child Dose

Clinical InformationAdministration Information
Indication: Venous Thromboembolism
Age: Birth (gestational age greater than 35 weeks) to less than 2 years
Dose: Subcutaneous Injection – 150 IU/kg
Frequency: twice daily
Note: Indicated for the treatment of symptomatic venous thromboembolism (VTE) to reduce the recurrence of VTE in pediatric patients
Indication: Venous Thromboembolism
Age: 2 to less than 8 years
Dose: Subcutaneous Injection – 125 IU/kg
Frequency: twice daily
Note: Indicated for the treatment of symptomatic venous thromboembolism (VTE) to reduce the recurrence of VTE in pediatric patients

Renal Dose

Clinical InformationAdministration Information
Condition: Renal impairment: Creatinine Clearance less than 30 mL/minute
Dose: Dosage adjustment needed
Note: Dosage adjustment needed based on anti-Factor Xa activity
Administration
  • For subcutaneous injection only
  • Give at same time daily
Side Effect

Drug Interaction

Drug NameRisk Factors
Other anticoagulant/antiplatelet agents (e.g. aspirin/dipyridamole, glycoprotein IIb/IIIa receptor antagonists, vit K antagonists, NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac), cytostatics, dextran, thrombolytics, sulfinpyrazone, probenecid, etacrynic acid)
Increased risk of haemorrhage
Antihistamines (Diphenhydramine, Loratadine, Levocetirizine, Cetirizine, Fexofenadine, Hydroxyzine, Bilastin), cardiac glycosides, tetracycline, ascorbic acid
Reduced anticoagulant effect

Disease Interaction

Disease NameRisk Factors
Active Major Bleeding
Risk of uncontrolled bleeding
Severe Coagulation Disorders
Risk of hemorrhage

Pregnancy

Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 20-25°C.

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.