Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Severe Gram-positive infections Age: Adult Condition: Initial dose |
Dose: Parenteral – 6 mg/kg Frequency: once daily Note: Administered on first day. Doses may be given via intramuscular injection, intravenous bolus or intravenous infusion over 30 minutes. |
|
Indication: Severe Gram-positive infections Age: Adult Condition: Maintenance dose |
Dose: Parenteral – 3 mg/kg Frequency: once daily Note: Followed by initial dose. Doses may be given via intramuscular injection, intravenous bolus or intravenous infusion over 30 minutes. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Severe Gram-positive infections Age: Child |
Dose: Parenteral – 10 mg/kg Frequency: every 12 hours Duration: for 3 doses Note: loading dose |
|
Indication: Severe Gram-positive infections Age: Child |
Dose: Parenteral – 6-10 mg/kg/day Note: maintenance dose following loading dose depending on severity of the infection |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment (Creatinine Clearance 40-60 ml/min) |
Dose: Parenteral – 1/2 initial dose Frequency: once daily or initial dose every 2 days Note: Usual dose to be given for first 3 days, thereafter adjust dose according to Creatinine Clearance |
|
Condition: Renal impairment (Creatinine Clearance less than 40 ml/min) |
Dose: Parenteral – 1/3 initial dose Frequency: once daily or initial dose every 3 days Note: Usual dose to be given for first 3 days, thereafter adjust dose according to Creatinine Clearance |
Administration
- Must be administered by healthcare professional
- For injection use only
Side Effect
- Fever
- chills
- allergic reactions
- GI disturbances
- headache
- dizziness
- "red-man" syndrome
- disturbances in liver enzymes
- renal impairment
- ototoxicity
- blood dyscrasias
- Pain
- erythema
- thrombophloebitis
- abscess at site of administration
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Other nephrotoxic and/or neurotoxic drugs
|
Interactions mentioned but effects not specified
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.