Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Osteoarthritis Age: Adult |
Dose: Oral Tablet – 600-1000 mg Frequency: twice daily Note: Dose adjusted according to response. Maximum: 1200 mg/day. Hepatic impairment: Dose adjustment not necessary. |
|
Indication: Rheumatoid arthritis Age: Adult |
Dose: Oral Tablet – 600-1000 mg Frequency: twice daily Note: Dose adjusted according to response. Maximum: 1200 mg/day. Hepatic impairment: Dose adjustment not necessary. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Juvenile Rheumatoid Arthritis Age: less than 6 years |
Dose: Safety and efficacy not established Note: Safety and efficacy not established |
|
Indication: Juvenile Rheumatoid Arthritis Age: 6-16 years |
Dose: Extended release tablet – 400 mg Frequency: once daily Note: by mouth (oral) |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Mild-to-moderate renal impairment |
Dose: Dosage Form – Dose adjustment not necessary Note: Dose adjustment not necessary |
|
Condition: Severe renal impairment |
Dose: Dosage Form – Not recommended Note: Not recommended |
Administration
- Take with food
- Take with water
Side Effect
- Dyspepsia (10%)
- Dizziness (3-9%)
- Nervousness (1-3%)
- Pruritus (1-3%)
- Blurred vision (1-3%)
- Depression (1-3%)
- Chills/fever (1-3%)
- Asthenia
- malaise
- Blurred vision
- Bronchospasm
- Dysuria
- urinary frequency
- Edema
- Melena
- Rash
- Tinnitus
- Acute renal failure
- blood disorder
- nephrotoxicity
- angioedema
- arrhythmia
- bone marrow suppression
- CHF
- dyspnoea
- erythema multiforme
- exfoliative dermatitis
- hepatitis
- hypertension
- peripheral neuropathy
- Stevens-Johnson syndrome
- syncope
- tachycardia
- toxic amblyopia
- toxic epidermal necrolysis
- urticaria
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Warfarin, Lithium, Methotrexate, Digoxin, Cyclosporin, Aspirin
|
Increased effect
|
|
Some diuretics and β-blockers
|
Reduced effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Peptic Ulcer
|
Risk of bleeding and perforation
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Do not store above 30°C. Keep away from light and out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.