Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Testicular Cancer, Squamous cell carcinoma of head and neck, Hodgkin's Disease, Kaposi's sarcoma, histiocytic lymphoma, mycosis fungoides, and Letterer-Siwe disease (histiocytosis X) Age: Adult |
Dose: Intravenous – 3.7 to 18 mg/square meter/day Frequency: every 7 to 10 days |
|
Indication: Testicular Cancer, Squamous cell carcinoma of head and neck, Hodgkin's Disease, Kaposi's sarcoma, histiocytic lymphoma, mycosis fungoides, and Letterer-Siwe disease (histiocytosis X) Age: Adult |
Dose: Intravenous – 3.7 mg/square meter/day Note: First dose. Increase by 1.85 mg/square meter every week until white blood cell count equals 3000/cubic millimeter. Not more than 18.5 mg/square meter. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Testicular CA, Squamous cell carcinoma CA of head and neck, Hodgkin's Disease, Kaposi's sarcoma, histiocytic lymphoma, mycosis fungoides, and Letterer-Siwe disease (histiocytosis X) |
Dose: Intravenous – 2.5-12.5 mg/square meter Frequency: every 7-10 days Note: General dosing ranges |
|
Indication: Testicular CA, Squamous cell carcinoma CA of head and neck, Hodgkin's Disease, Kaposi's sarcoma, histiocytic lymphoma, mycosis fungoides, and Letterer-Siwe disease (histiocytosis X) Condition: 1st dose |
Dose: Intravenous – 2.5 mg/square meter Note: First dose |
Administration
- For IV use only
- Must be diluted correctly
Side Effect
- Anemia
- Leukopenia
- Myelosuppression
- Alopecia
- Peripheral neuropathy
- Hypertension
- Bronchospasm
- Nausea
- Vomiting
- Anorexia
- Diarrhea
- Constipation
- Paralytic ileus
- Jaw pain
- Aspermia
- Amenorrhea
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Aprepitant
|
Possible increase in vinblastine levels
|
|
Miconazole
|
Reduced vinblastine metabolism
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Bone Marrow Suppression
|
Risk of infection and bleeding
|
|
Bacterial Infection
|
May worsen infection
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 2-8° C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.