Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Systemic Infections Age: Adult Condition: Moderately severe |
Dose: Intravenous or Intramuscular – 1-2 g Frequency: every 8-12 hours Note: not to exceed 8 g/day |
|
Indication: Systemic Infections Age: Adult Condition: Severe or life-threatening |
Dose: Intravenous or Intramuscular – 2 g Frequency: every 6-8 hours Note: not to exceed 8 g/day |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Intravenous, Intramuscular – 90–120 mg/kg/day Frequency: every 6 to 8 hours |
|
Age: Infants greater than 1 week |
Dose: – 30 mg/kg Frequency: every 6 or 8 hours |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment Creatinine Clearance 10-30 mL/minute |
Dose: 1-2 g loading dose, then 50% of usual dosage Note: Renal impairment |
|
Condition: Renal impairment Creatinine Clearance less than 10 mL/minute |
Dose: 1-2 g loading dose, then 25% of usual dosage Note: Renal impairment |
Administration
- Hospital use only
- Given by injection
Side Effect
- Pain at injection site (12% children) (2%, adults)
- Increase in serum transaminases (4-6%)
- Neutropenia (3-11%, children)
- (Less than 1% adults)
- Rash (4%)
- Thrombocytopenia (4% children)
- (Less than 1% adults)
- Diarrhea (1%)
- Nausea (1%)
- Vomiting (1%)
- Fever (Less than 1%)
- Abnormal taste
- Anaphylaxis
- Anemia
- Angioedema
- Aphthous ulcer
- Breast tenderness
- Bronchospasm
- Clostridium difficile-associated diarrhea (CDAD)
- Confusion
- Diplopia
- Dizziness
- Dsypnea
- Electrocardiographic changes (transient)
- Erythema multiforme
- Eosinophilia
- Fever
- Flushing
- Halitosis
- Headache
- Hepatitis
- Hypotension
- Insomnia
- Jaundice
- Leukocytosis
- Neutropenia
- Pancytopenia
- Seizures
- Thrombocytopenia
- Tinnitus
- Tongue numbness
- Toxic epidermal necrolysis
- Urticaria
- Vaginitis
- Vertigo
- Weakness
- Wheezing
- Clostridium difficile-associated diarrhoea from mild diarrhoea to fatal colitis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Oral Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban)
|
May increase prothrombin time
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool & dry place, protected from light & moisture. Keep all medicines out of reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.