Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Spasticity resulting from multiple sclerosis Age: Adult |
Dose: Oral - 5 mg Frequency: three times daily Duration: for 3 days Note: Initial dose. |
|
Indication: Spasticity resulting from multiple sclerosis Age: Adult |
Dose: Oral - 10 mg Frequency: three times daily Duration: for 3 days Note: Increased dose after initial 3 days. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Spasticity Age: Child |
Dose: Oral – 0.75-2 mg/kg Frequency: daily Note: May initiate with 2.5 mg four times daily, increased gradually every 3 days until the desired effect is obtained |
|
Indication: Spasticity Age: 6-10 years |
Dose: Oral – 30-60 mg Frequency: daily Note: Maintenance dose |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Dose: Note: Renal impairment: Dose reduction may be required. |
Administration
- Take with food
- Take at regular intervals
Side Effect
- Drowsiness, transient (10-63%)
- Dizziness (5-15%)
- Nausea (4-12%)
- Confusion (1-11%)
- Headache (4-8%)
- Insomnia (2-7%)
- Constipation (2-6%)
- Urinary frequency (2-6%)
- Fatigue (2-4%)
- Abdominal pain
- Ankle edema
- Anorexia
- Ataxia
- Blurred vision
- Chest pain
- Coordination disorder
- Depression
- Diarrhea
- Dry mouth
- Diplopia
- Dysarthria
- Dyspnea
- Dystonia
- Enuresis
- Euphoria
- Excitement
- Hallucinations
- Hematuria
- Hypotension
- Impotence
- Miosis
- Muscle pain
- Mydriasis
- Nasal congestion
- Nocturia
- Nystagmus
- Palpitation
- Paresthesia
- Excessive perspiration
- Pruritus
- Rash
- Rigidity
- Seizure
- Strabismus
- Slurred speech
- Syncope
- Tinnitus
- Tremor
- Urinary retention
- Vomiting
- Weight gain
- Respiratory or CV depression
- seizures
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Antihypertensive (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril, Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, Propranolol, Metoprolol, Atenolol, Carvedilol, Bisoprolol, Nadolol, Amlodipine, Diltiazem, Verapamil, Nifedipine, Nicardipine, Hydrochlorothiazide, Chlorthalidone, Indapamide, Furosemide, Bumetanide, Torsemide, Spironolactone, Amiloride, Triamterene, Prazosin, Doxazosin, Terazosin, Clonidine, Methyldopa, Hydralazine, Minoxidil)
|
Hypotensive effect may be increased
|
|
Levodopa
|
May result in confusion, agitation, hallucinations in Parkinson patients
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Active Peptic Ulcer Disease
|
Can worsen ulcer
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.