Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Nosocomial pneumonia Age: Adult |
Dose: Intravenous Injection – 4.5 g (piperacillin 4 g and tazobactam 0.5 g) Frequency: every 6 hours Duration: 5-14 days Note: Administer by infusion over 30 minutes. When used empirically, combination with aminoglycoside or antipseudomonal fluoroquinolone is recommended. |
|
Indication: Empiric therapy for febrile neutropenic patients Age: Adult |
Dose: Intravenous Injection – 4.5 g (piperacillin 4 g and tazobactam 0.5 g) Frequency: every 6 hours Duration: 5-14 days Note: Administer by infusion over 30 minutes. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Intravenous – 240–300 mg piperacillin/kg/day Frequency: every 8 hours |
|
Indication: Nosocomial pneumonia Age: Child (2-12 years) |
Dose: Intravenous – 90 mg/kg (80 mg/kg piperacillin and 10 mg/kg tazobactam) Frequency: every 6 hours Duration: 5-14 days Note: infusion over 30 minutes. Maximum: 4.5 g per dose |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Haemodialysis |
Dose: 2.25 g Frequency: every 12 hours Note: Additional dose of 0.75 g after each dialysis session |
|
Condition: Continuous Ambulatory Peritoneal Dialysis |
Dose: 2.25 g Frequency: every 12 hours |
Administration
- For IV use only
- Must be diluted before use
Side Effect
- Diarrhea (7-11%)
- Constipation (1-8%)
- Headache (1-8%)
- Insomnia (4-7%)
- Nausea (2-7%)
- Fever (2-5%)
- Oral candidiasis (2-4%)
- Rash (2-4%)
- Vomiting (2-4%)
- Dyspepsia (3%)
- Pruritus (3%)
- Pain (2-3%)
- Hypertension (2%)
- Leukopenia (1%)
- Thrombocytopenia (1.4%)
- Anaphylaxis
- Agranulocytosis
- Thrombocytopenia
- Eosinophilia
- Leukopenia
- Positive Coombs test
- Prolonged PT and PTT
- Transient LFT and creatinine elevations
- Seizure
- Pulmonary edema
- Pulmonary embolism
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Heparin, Oral Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban)
|
Interacts with high doses
|
|
Vecuronium, Non-depolarising Muscle Relaxants (Baclofen, Cyclobenzaprine, Tizanidine, Dantrolene)
|
Prolongs neuromuscular blockade
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.