Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Prophylaxis against urothelial toxicity Condition: With Ifosfamide (if receiving 1.2 grams/square meter ifosfamide dose) |
Dose: Intravenous push – 240 mg/square meter Frequency: 15 minutes before and 4 and 8 hours after ifosfamide administration Note: Adjust dose accordingly if ifosfamide dose changes. Also given by alternative intravenous push regimens, intermittent infusion or continuous infusion. |
|
Indication: Prophylaxis against urothelial toxicity Condition: With Ifosfamide (if receiving 1.2 grams/square meter ifosfamide dose) |
Dose: Intravenous push – 240 mg/square meter Frequency: 15 minutes before ifosfamide administration Note: Followed by oral doses. Adjust dose accordingly if ifosfamide dose changes. Also given by alternative intravenous push regimens, intermittent infusion or continuous infusion. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Tablet – No approved pediatric dosage available Note: No approved pediatric dosage available |
Administration
- Given through IV or infusion
- Should be given 15 minutes before chemotherapy
Side Effect
- Nausea (More than 50%)
- Vomiting (29%)
- Anorexia
- Asthenia
- Fatigue
- Fever
- Abdominal pain
- Constipation
- Anemia
- Granulocytopenia
- Leukopenia
- Thrombocytopenia
- Alopecia
- Anxiety
- Confusion
- Dizziness
- Headache
- Insomnia
- Pain
- Somnolence
- Chest pain
- Edema
- Flushing
- Tachycardia
- Cough
- Dyspnea
- Pneumonia
- Diarrhea
- Hematuria
- Hypokalemia
- Back pain
- Dehydration
- Injection site reaction
- Pallor
- May cause haemorrhagic cystitis
- systemic anaphylactic reactions
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Cisplatin, Nitrogen mustard
|
Incompatible in vitro
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Should be stored at 15-30° C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.