Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Urine alkalinisation to prevent development of uric-acid renal calculi in the initial stages of uricosuric therapy for hyperuricaemia in chronic gout Age: Adult |
Dose: Oral – Up to 10 g Frequency: daily in divided doses Note: To be taken with a liberal amount of fluid. |
|
Indication: Chronic metabolic acidosis Age: Adult |
Dose: Oral – 57 mmol (4.8 g sodium bicarbonate) or more Frequency: daily as required |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Cardiac arrest Age: Children |
Dose: Intravenous – 1 mmol/kg Note: Intravenous |
|
Indication: Cardiac arrest Age: Infants (up to 2 years of age) |
Dose: Intravenous – 1 mmol/kg (diluted 1:1 to 4.2% solution) Note: Intravenous |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Not specified Note: Dosage adjustments may be required |
Administration
- Take on empty stomach
- Take 1 hour before or 2 hours after food
Side Effect
- Aggravated CHF
- Cerebral hemorrhage
- Edema
- Hypernatremia
- Hypocalcemia
- Hypokalemia
- Tetany
- Tissue necrosis at Injection site
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Amphetamines, Ephedrine, Pseudoephedrine, Flecainide, Quinidine, Quinine
|
Increases toxicity
|
|
Lithium, Chlorpropamide, Salicylates
|
Decreases effects due to increased clearance
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Metabolic Alkalosis
|
Can worsen alkalosis
|
|
Respiratory Alkalosis
|
Can worsen pH imbalance
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool & dry place protected from light. Keep out of reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.