Medicine Overview

Indication
Know Medicine, Follow Guideline

Adult Dose
Clinical InformationAdministration Information
Indication: Muscle relaxant in general anaesthesia; Facilitate endotracheal intubation; Facilitate mechanical ventilation in intensive care
Age: Adult
Dose: Injection – Initially, 80-100 mcg/kg
Note: administered by injection
Indication: Muscle relaxant in general anaesthesia; Facilitate endotracheal intubation; Facilitate mechanical ventilation in intensive care
Age: Adult
Dose: Injection – Maintenance: 20-30 mcg/kg
Note: administered by injection

Child Dose
Clinical InformationAdministration Information
Indication: Muscle relaxant in general anaesthesia; Facilitate endotracheal intubation; Facilitate mechanical ventilation in intensive care
Age: Child less than 4 months
Dose: Intravenous – 10-20 mcg/kg
Note: Initial test dose, with increments according to response
Indication: Muscle relaxant in general anaesthesia; Facilitate endotracheal intubation; Facilitate mechanical ventilation in intensive care
Age: Child greater than 4 months
Dose: Intravenous – 80-100 mcg/kg
Note: by injection
Administration
  • For hospital use only
  • Must be administered by healthcare professionals
Side Effect

Drug Interaction
Drug NameRisk Factors
Volatile anaesthetic agents (halothane, ether, enflurane, isoflurane, methoxyflurane, propofol, cyclopropane), fentanyl, other non-depolarising Muscle Relaxants (Baclofen, Cyclobenzaprine, Tizanidine, Dantrolene), succinylcholine, tetracyclines, polymyxins, diuretics, thiamine, MAOIs (Phenelzine, Tranylcypromine, Selegiline, Moclobemide), bacitracin, colistin, sodium colistimethate, acylaminopenicillins, Aminoglycoside Antibiotics (Gentamicin, Amikacin, Tobramycin, Neomycin, Streptomycin, Paromomycin), high dose metronidazole, protamine, beta-adrenergic blocking agents, calcium antagonists (e.g. verapamil), magnesium
Increases neuromuscular blockade
Anticholinesterases, prior chronic admin of Corticosteroids (Prednisone, Prednisolone, Methylprednisolone, Dexamethasone, Hydrocortisone), phenytoin, carbamazepine, noradrenaline, azathioprine, theophylline, calcium chloride
Decreased neuromuscular blockade

Disease Interaction
Disease NameRisk Factors
No specific contraindications listed
Monitor for general drug reactions

Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 20-25° C. Protect from light.

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.