Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypercholesterolemia and Mixed Dyslipidemia Age: Adult |
Dose: Oral – 20-40 mg Frequency: once daily in the evening Note: May increase at intervals of 4 weeks to maximum 80 mg/day in 12 hourly divided dose. Contraindicated in active liver disease or unexplained transaminase elevations. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Heterozygous familial hypercholesterolaemia Age: 10-16 years |
Dose: Oral – 20 mg Frequency: once daily |
|
Indication: Heterozygous familial hypercholesterolaemia Age: 10-16 years Condition: If necessary |
Dose: Oral – 40 mg Frequency: twice daily Note: dose may be increased at 6-weekly intervals |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment |
Dose: Not specified – Not specified Note: Adjust dose amount; not to exceed 40 mg/day |
Administration
- Can be taken with or without food
- Take at same time daily
Side Effect
- Headache (9%)
- Dyspepsia (8%)
- Abdominal pain (5%)
- Diarrhea (5%)
- Myalgia (5%)
- Fatigue (3%)
- Insomnia (3%)
- Nausea (3%)
- Sinusitis (3%)
- Bronchitis (2%)
- UTI (2%)
- Transaminases increased (1.1%)
- Rash
- Back pain
- Arthralgia
- Myopathy
- Rhabdomyolysis
- Rupture of tendon
- CPK increased
- Pharyngitis
- Rhinitis
- Cough
- Constipation
- Pancreatitis
- Dizziness
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Coumarin Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban)
|
Bleeding and increased prothrombin time
|
|
HIV Protease Inhibitors (Ritonavir, Atazanavir, Lopinavir, Nelfinavir, Saquinavir, Indinavir), colchicine, bezafibrate, ciprofibrate, niacin (nicotinic acid), ciclosporin, fluconazole
|
May increase the risk of myopathy and rhabdomyolysis
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Acute liver disease
|
Can cause serious liver damage
|
|
Porphyria
|
Can trigger acute attacks
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 15-30° C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.