Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Immunosuppression in organ transplantation Age: Adult |
Dose: Oral – Initially, 10-15 mg/kg/day Duration: starting 4-12 hours before procedure and continued for 1-2 weeks Note: Usual maintenance: 2-6 mg/kg/day. Lower doses may be used when combined with other immunosuppressants. |
|
Indication: Severe Atopic dermatitis, Psoriasis Age: Adult |
Dose: Oral – Initially, 2.5 mg/kg/day Frequency: in 2 divided doses Note: Reduce to the lowest effective dose once remission is achieved. Stop treatment if there is no sufficient improvement to maximum dose within 6 weeks. Maximum: 5 mg/kg/day. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Nephrotic syndrome Age: Child |
Dose: Oral – 6 mg/kg daily Frequency: given in 2 divided doses |
Administration
- Take consistently with/without food
- Take at same times
Side Effect
- Tremor (12-55%)
- Nephrotoxicity (32%)
- Hypertension (26%)
- Infection (3-25%)
- Headache (2-25%)
- Nausea (23%)
- Hirsutism (21%)
- Hypertrichosis (5-19%)
- Female reproductive disorder (5-19%)
- Gum hyperplasia (2-16%)
- Triglycerides increased (15%)
- Abdominal discomfort (1-15%)
- URI (1-14%)
- Diarrhea (3-13%)
- Dyspepsia (2-12%)
- Leg cramps (2-12%)
- Parathesia (1-11%)
- Acne
- Convulsions
- Pruitus
- Hyperkalemia
- hypomagnesemia
- Pancreatitis
- Hepatotoxicity
- Flu-like syndrome
- Leukopenia
- Thrombocytopenia
- Anaphylaxis
- Glomerular capillary thrombosis
- Hypomagnesemia
- Migraine
- Hyponatremia
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Diltiazem, Doxycycline, Erythromycin, Ketoconazole, Methylprednisolone (high doses), Nicardipine, Verapamil, Oral contraceptives
|
Increased cyclosporin level
|
|
Carbamazepine, Isoniazid, Phenobarbital, Phenytoin, Rifampicin
|
Reduce cyclosporin level
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Malignant Neoplasms
|
May increase cancer progression
|
|
Uncontrolled Hypertension
|
Can worsen blood pressure
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Sporium oral solution should be used within 2 months of opening the bottle and be stored between 15 to 30° C, preferably not below 20° C for prolonged periods, as it contains oily components which tend to solidify at low temperatures. A jelly-like formation may occur below 20° C, which is reversible at temperatures up to 30° C. Slight sediment may still be observed which does not affect the efficacy and safety of the product.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.