Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Moderately Severe Acute Pain Age: Adult Condition: Short-term (less than 5 days) management that requires analgesia at opioid level |
Dose: Intravenous – 30 mg Frequency: as a single dose or every 6 hours Duration: not to exceed 5 days Note: not indicated for minor or chronic painful conditions; not to exceed 120 mg/day; always begin with parenteral therapy |
|
Indication: Moderately Severe Acute Pain Age: Adult Condition: Short-term (less than 5 days) management that requires analgesia at opioid level |
Dose: Intramuscular – 60 mg Frequency: as a single dose Duration: not to exceed 5 days Note: not indicated for minor or chronic painful conditions; always begin with parenteral therapy |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: less than 2 years |
Dose: Intravenous/Intramuscular – Safety and efficacy not established Note: Safety and efficacy not established |
|
Age: 2-16 years |
Dose: Intravenous/Intramuscular – 0.5 mg/kg Frequency: once Note: Single dose; not to exceed 15 mg |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Severe renal impairment |
Dose: Injection – Contraindicated Note: Contraindicated in severe renal impairment |
|
Condition: Moderate renal impairment (moderately elevated serum creatinine) |
Dose: Intramuscular or Intravenous – 50% of recommended dosage Note: Not to exceed 60 mg/day intramuscular/intravenous |
Administration
- Take as directed
- Short-term use only
Side Effect
- Headache (17%)
- Somnolence (3-14%)
- Dyspepsia (12-13%)
- GI pain (12-13%)
- Nausea (12-13%)
- Diarrhea (3-9%)
- Dizziness (3-9%)
- Pruritus (3-9%)
- Edema (1-3%)
- Increased blood urea nitrogen (BUN) (3%)
- Constipation (Less than 3%)
- Purpura (Less than 3%)
- Increased serum creatinineeatinine (2%)
- Drowsiness (6%)
- Hypertension (4%)
- Abnormal thinking
- Anaphylaxis
- Blurred vision
- Bronchospasm
- Cholestatic jaundice
- Depression
- Difficulty in concentration
- Dysgeusia
- Euphoria
- Hemolytic-uremic
- syndrome
- Hepatitis
- Hyperkalemia
- Hyponatremia
- Hypotension
- Increased liver function test values
- Insomnia
- Laryngeal/lingual edema
- Liver failure
- Melena
- Nervousness
- Oliguria
- Pallor
- Peptic ulcer
- Rash
- Rectal bleeding
- Stomatitis
- Urinary frequency
- Urinary retention
- Vasodilation
- Anaphylaxis
- Severe skin reactions
- MI
- stroke
- GI bleeding
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
ACE Inhibitors (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril), Angiotensin II receptor antagonists
|
May reduce effects of antihypertensives
|
|
ACE Inhibitors (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril), Diuretics (Chlorothiazide, Chlorthalidone, Hydrochlorothiazide, Indapamide, Metolazone, Bumetanide, Ethacrynic acid, Furosemide, Torsemide, Amiloride, Eplerenone, Spironolactone, Triamterene)
|
Increased risk of renal toxicity
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Asthma
|
Risk of severe bronchospasm
|
|
Hypovolaemia
|
Can worsen circulatory status
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep in a dry place away from light and heat. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.