Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Treatment of pellagra Age: Adult |
Dose: Oral – 300-500 mg Frequency: daily in divided doses |
|
Indication: Management of Hartnup disease Age: Adult |
Dose: Oral – 50-200 mg Frequency: daily |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: treatment of pellagra Age: Child |
Dose: Oral – 100-300 mg Frequency: daily in divided doses Note: Treatment and prophylaxis of nicotinic acid deficiency |
Administration
- Take with food
- Take at bedtime after low-fat snack
Side Effect
- Flushing
- sensation of heat
- faintness
- pounding in the head
- tingling
- itching
- headache
- dizziness
- tachycardia
- palpitations
- dyspnoea
- sweating
- chills
- oedema
- dryness of skin
- pruritus
- hyperpigmentation
- rash
- cramps
- cough
- diarrhoea
- nausea and vomiting
- anorexia
- activation of peptic ulcer
- eye disorders including Cystoid macular edema and toxic amblyopia
- decreased glucose tolerance
- hyperglycaemia
- hyperuricaemia
- abnormal LFTs
- jaundice
- hypophosphataemia
- reduced platelet counts
- prolonged prothrombin time
- arrhythmias
- hypersensitivity reactions including angioedema
- insomnia
- myalgia and hypotension
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
HMG-CoA reductase inhibitors
|
Increased risk of myopathy and rhabdomyolysis
|
|
Colestyramine, Colestipol
|
Reduced bioavailability
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Significant Hepatic Dysfunction
|
Risk of liver toxicity
|
|
Active Peptic Ulcer
|
May worsen ulcer condition
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.