Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Type 2 diabetes mellitus Age: Adult |
Dose: Oral – 2.5 or 5 mg Frequency: once daily |
|
Indication: Type 2 diabetes mellitus Age: Adult Condition: Combination therapy |
Dose: Oral Note: May need to reduce dosage of sulfonylurea or other insulin secretagogues when administered in combination |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Safety and efficacy not established Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Creatinine clearance greater than 50 mL/min Condition: Renal impairment |
Dose: Tablet – No dose adjustment required Note: No dose adjustment required |
|
Indication: Creatinine clearance less than 50 mL/min Condition: Renal impairment |
Dose: Tablet – 2.5 mg Frequency: once daily Note: Not to exceed 2.5 mg by mouth once daily |
Administration
- Can be taken with or without food
- Take at same time daily
Side Effect
- Urinary Tract Infection (UTI) (7%)
- Headache (7%)
- Hypersensitivity-related events (Less than 4%, eg urticaria, facial edema)
- Peripheral edema (Less than 4%
- increased incidence when coadministrationistered with thiazolidinediones)
- Upper respiratory tract infection (URTI) (3%)
- Gastroenteritis (2%)
- Hypoglycemia (1.6%)
- Increased creatinine phosphokinase
- Increased creatinine
- Idiopathic thrombocytopenic purpura rash
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Ketoconazole, Atazanavir, Clarithromycin, Indinavir, Itraconazole, Nefazodone, Nelfinavir, Ritonavir, Saquinavir, Telithromycin
|
Strong CYP3A4/5 inhibitors may affect saxagliptin levels
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Documented Hypersensitivity
|
Risk of severe reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 20-25° C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.