Medicine Overview

Indication

Know Medicine, Follow Guideline

Adult Dose

Clinical InformationAdministration Information
Indication: Moderate to severe pain
Age: Adult
Dose: Tablet – 1-2 tablet
Frequency: every 6 hours
Duration: Maximum duration: 5 days
Note: Maximum: 8 tablets/day.
Indication: Moderate to severe pain
Age: Adult
Condition: Moderate hepatic impairment
Dose: Tablet – 1-2 tablet
Frequency: Increased dosing interval
Note: General adult dose is 1-2 tablets every 6 hours with a maximum of 8 tablets/day and maximum duration of 5 days.

Child Dose

Clinical InformationAdministration Information
Age: Child
Dose: Tablet – No approved pediatric dosage available
Note: No approved pediatric dosage available

Renal Dose

Clinical InformationAdministration Information
Condition: Renal impairment: Creatinine Clearance 10-30 mL/min
Dose: Not specified
Frequency: every 12 hours
Note: Increase dosing interval to 12 hourly.
Condition: Renal impairment: Creatinine Clearance less than 10 mL/min
Dose: Not specified
Note: Not recommended.
Administration
  • May be taken with or without food
  • Take with full glass of water
Side Effect

Drug Interaction

Drug NameRisk Factors
SSRIs, SNRIs, TCAs, 5-HT agonists
Increased risk of seizures and serotonin syndrome
Barbiturates, Benzodiazepines (Diazepam, Alprazolam, Lorazepam, Clonazepam, Midazolam), Anxiolytics, Hypnotics, Sedative Antidepressants (Fluoxetine, Sertraline, Paroxetine, Citalopram, Escitalopram, Venlafaxine, Duloxetine), Sedative Antihistamines (Diphenhydramine, Loratadine, Levocetirizine, Cetirizine, Fexofenadine, Hydroxyzine, Bilastin), Neuroleptics, Centrally-acting antihypertensive drugs, Thalidomide, Baclofen
Increased CNS depression

Disease Interaction

Disease NameRisk Factors
Acute Alcohol Intoxication
Risk of liver toxicity
Severe Hepatic Impairment
Increased risk of toxicity

Pregnancy

Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place. Do not freeze. Keep all medicines out of the reach of children.

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.