Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Moderate to severe pain Age: Adult |
Dose: Oral – 5-20 mg Frequency: every 4 hours Note: Dosage is dependent on the severity of pain. |
|
Indication: Moderate to severe pain Age: Adult |
Dose: Extended-release Oral – 5-20 mg Frequency: every 12 hours Note: Dosage is dependent on the severity of pain. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Analgesia Age: Neonates (less than 30 days) Condition: Cyanotic Tetralogy of Fallot |
Dose: Intramuscular/Subcutaneous – 0.3-1.2 mg/kg/day Frequency: divided every 4 hours |
|
Indication: Analgesia Age: Neonates (less than 30 days) Condition: Cyanotic Tetralogy of Fallot |
Dose: slow Intravenous – 0.005-0.03 mg/kg/hr Note: slow intravenous infusion |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Dosage Form – Dosage may need to be reduced Note: Renal impairment: Dosage may need to be reduced. |
Administration
- May be taken with or without food
- IV push: Give over 4-5 minutes
Side Effect
- Pruritus (≤80%)
- Urinary retention (epidural/IT) (15-70%)
- Vomiting (7-70%)
- Constipation (More than 10%)
- Headache (More than 10%)
- Somnolence (More than 10%)
- Abdominal pain (5-10%)
- Asthenia (5-10%)
- Backache (5-10%)
- Depression (5-10%)
- Diarrhea (5-10%)
- Dyspnea (5-10%)
- Fever (5-10%)
- Insomnia (5 -10% )
- Loss of appetite (5-10%)
- Nausea (5-10%)
- Paresthesia (5-10%)
- Peripheral edema (5-10%)
- Rash (5-10%)
- Sweating (5-10%)
- Xerostomia (5-10%)
- Respiratory depression (IT) (4-7%)
- Anxiety (6%)
- Dizziness (6%)
- Abnormal liver function test results (Less than 5%)
- Amblyopia (Less than 5%)
- Hiccups (Less than 5%)
- Orthostatic hypotension (Less than 5%)
- Syncope (Less than 5%)
- Urinary retention (PO) (Less than 5%)
- Respiratory depression (epidural) (0.25-0.4%)
- Anaphylaxis (rare )
- Cardiac arrest
- Circulatory depression
- Finding of intracranial pressure
- Ileus
- Lightheadedness
- Malaise
- Miosis
- Myoclonus
- Shock
- Thinking disturbances
- Vertigo
- Respiratory depression
- circulatory failure
- hypotension
- deepening coma
- anaphylactic reactions
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Sedatives, Hypnotics, General anaesthetics, Phenothiazines, Tranquilizers
|
Additive depressant effects
|
|
Skeletal Muscle Relaxants (Baclofen, Cyclobenzaprine, Tizanidine, Dantrolene)
|
May enhance neuromuscular blocking action
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Respiratory Depression
|
Can worsen breathing
|
|
Acute/Severe Asthma
|
Risk of severe breathing difficulty
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Inj/oral preparations: Store between 15-30°C. Liposomal inj: Store between 2-8°C. Supp: Store below 25°C. Protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.