Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension |
Dose: Oral Tablet – Initiate with 5 mg amlodipine / 160 mg valsartan Frequency: once daily Note: May be substituted for individually titrated components; may increase dose after at least 2 weeks, not to exceed 10 mg/day amlodipine and 320 mg/day valsartan; may be administered concomitantly with other antihypertensive agents. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Form – No approved dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Mild or moderate (Creatinine Clearance greater than 30 mL/minute) |
Dose: Dose: Note: Dose adjustment not necessary |
|
Condition: Severe (Creatinine Clearance less than 30 mL/minute) |
Dose: Dose: Note: Not studied |
Administration
- Take with or without food
- Take at same time daily
Side Effect
- Headache
- Increased BUN (6-17%)
- Peripheral edema (5-8%)
- Anxiety (3%)
- Nasopharyngitis (4%)
- Increased potassium (3%)
- Upper respiratory infection (3%)
- Dizziness (2%)
- Somnolence (3%)
- Diarrhea (3%)
- Nausea (3%)
- Abdominal pain (3%)
- Cough (2%)
- Orthostatic hypotension
- Syncope
- Visual disturbance
- Tinnitus
- Exanthema
- Hypotension
- bradycardia
- conductive system delay and CCF
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
CYP3A4 inhibitors (Azole Antifungals (Fluconazole, Itraconazole, Ketoconazole, Voriconazole, Posaconazole), ritonavir)
|
Elevates Amlodipine plasma concentrations
|
|
Simvastatin
|
Increased risk of myopathy including rhabdomyolysis
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.