Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Bronchitis Exacerbation, Community Acquired Pneumonia, Skin & Skin Structure Infections Age: Adult |
Dose: Oral – 400 mg Frequency: twice daily Duration: 10 days |
|
Indication: Uncomplicated gonorrhoea Age: Adult |
Dose: Oral – 400 mg Frequency: single dose |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Not specified Note: Not indicated |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: CrCl (ml/min) 20-50 |
Dose: Oral – Reduce dose by half Frequency: every 24 hours Note: following usual initial dose. |
|
Condition: Renal impairment: CrCl (ml/min) less than 20 and patients on haemodialysis or peritoneal dialysis |
Dose: Oral – 100 mg Frequency: every 24 hours Note: following usual initial dose. |
Administration
- May be taken with or without food
- Avoid dairy products within 2 hours
Side Effect
- Nausea (3-10%)
- Headache (1-9%)
- Insomnia (3-7%)
- Dizziness (1-5%)
- Vaginitis (1-5%)
- Diarrhea (1-4%)
- Vomiting (1-4%)
- Appetite decreased (1-3%)
- Abdominal cramps (1-3%)
- Abnormal taste (1-3%)
- Chest pain (1-3%)
- External genital pruritis in women (1-3%)
- Fatigue (1-3%)
- Flatulence (1-3%)
- GI distress (1-3%)
- Nervousness (1-3%)
- Pharyngitis (1-3%)
- Pyrexia (1-3%)
- Rash/pruritis (1-3%)
- Sleep disorders (1-3%)
- Visual disturbances (1-3%)
- Xerostomia (1-3%)
- Prolonged QT interval
- Torsades de pointes
- Syncope
- Vasculitis
- Edema
- HTN
- Palpitations
- Vasodilation
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Agranulocytosis
- Aplastic anemia
- Pancytopenia
- Thrombocytopenia
- Thrombocytopenic purpura
- Acute hepatitis
- Hepatic failure
- Hepatic necrosiImmune hypersensitivity reaction
- Rupture of tendon
- Tendinitis
- Peripheral neuropathy
- Seizure
- Acute renal failure
- Interstitial nephritis
- Renal impairment
- Tourette's syndrome
- Decrease hearing acuity
- Anaphylaxis
- rarely seizures
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Class IA or III antiarrhythmic agents
|
May increase risk of QT interval prolongation
|
|
Antacids containing Mg, Al or Ca
|
Decreased serum and urine concentrations
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Prolonged QT Interval
|
Risk of dangerous heart rhythm
|
|
Uncorrected Hypokalemia
|
Risk of cardiac arrhythmias
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 15-30° C. Protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.