Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Supraventricular and ventricular arrhythmias, Atrial Fibrillation/Flutter Age: Adult |
Dose: Immediate-release tablet – 150 mg Frequency: three times daily Note: Usual initial dose. May increase at intervals of 3-4 days up to 300 mg three times daily. Dose reduction is recommended in patients weighing less than 70 kg. |
|
Indication: Supraventricular and ventricular arrhythmias, Atrial Fibrillation/Flutter Age: Elderly |
Dose: Immediate-release tablet – 150 mg Frequency: three times daily Note: Usual initial dose. Dose reduction is recommended. May increase at intervals of 3-4 days up to 300 mg three times daily. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Form – Not specified Note: Safety and efficacy not established |
Administration
- Take with food
- Swallow whole, do not crush
Side Effect
- Unusual taste (7-23%)
- Dizziness/lightheadedness (7-15%)
- N/V (3-11%)
- Constipation (4-8%)
- Headache (2-6%)
- Intraventricular conduction delay (4%)
- Fatigue (6%)
- Blurred vision (3%)
- Weakness (3%)
- Dyspnea (2%)
- Wild complex tachycardia (2%)
- Bradycardia (2%)
- Palpitations (2%)
- Tremor (2%)
- Anorexia (2%)
- Diarrhea (2%)
- Ataxia (2%)
- 1°AV block (2-5%)
- Angina (5%)
- Palpitations (3%)
- CHF (2-3% )
- Chest pain (2%)
- Bradyarrhythmia (2%)
- AF (1%)
- Bundle branch block (1%)
- 2nd degree AV block (1%)
- Hypotension (1%)
- Sinus arrest (1%)
- Lethargy
- Rash
- Dyspepsia
- Dry mouth
- Agranulocytosis
- Hepatotoxicity (rare)
- Systemic lupus erythematosus (rare)
- Bronchospasm (rare)
- SA/AV or intraventricular blocks
- Severe hypotension
- especially in elderly
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Local anesthetics, Beta-blockers (Propranolol, Metoprolol, Atenolol, Bisoprolol, Carvedilol, Nadolol, Timolol, Sotalol), TCAs
|
Effect may be potentiated
|
|
Propranolol, Metoprolol, Desipramine, Cyclosporin, Digoxin, Theophylline
|
May increase plasma level
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Uncontrolled Heart Failure
|
Worsens heart function
|
|
Severe Bradycardia
|
Dangerous slowing of heart rate
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 25° C. Store in a cool and dry place, protected from light. Keep out of children’s reach.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.