Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Inflammatory bowel disease Age: Adult Condition: Initial treatment |
Dose: Oral – 1-2 g Frequency: four times daily Duration: until remission occurs Note: Hepatic impairment: Avoid use. |
|
Indication: Inflammatory bowel disease Age: Adult Condition: Maintenance |
Dose: Oral – 2 g/day Frequency: in divided doses Note: Hepatic impairment: Avoid use. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Inflammatory bowel disease Age: Child: greater than 2 years |
Dose: Oral – 40-60 mg/kg/day Frequency: in divided doses |
|
Indication: Inflammatory bowel disease Age: Child: greater than 2 years Condition: Maintenance |
Dose: Oral – 20-30 mg/kg/day Frequency: in divided doses |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Creatinine Clearance 10-30 mL/min |
Dose: Renal Dose – Not specified Frequency: twice daily Note: Renal impairment |
|
Condition: Creatinine Clearance less than 10 mL/min |
Dose: Renal Dose – Not specified Frequency: once daily Note: Renal impairment |
Administration
- Take with food
- Take after meals
Side Effect
- Anorexia (~33%)
- Headache (~33%)
- Nausea (~33%)
- Vomiting (~33%)
- Gastric distress (~33%)
- Apparently reversible oligospermia (~33%)
- Skin rash
- Pruritus
- Urticaria
- Fever
- Heinz body anemia
- Hemolytic anemia
- Cyanosis
- Severe hypersensitivity reactions
- blood dyscrasias
- renal and hepatic toxicity
- fibrosing alveolitis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Rifampicin, Ethambutol
|
Plasma levels reduced
|
|
Folic acid
|
Interferes with absorption
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hypersensitivity to Sulfonamides/Salicylates
|
Can cause severe allergic reactions
|
|
Blood Dyscrasias/Leucopenia
|
Can worsen blood disorders
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place, protected from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.