Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Chronic Hepatitis C Age: Adult Condition: Genotype 1 or 4 (HCV Mono-infected and HCV/HIV-1 Co-infected) |
Dose: Tablet – 400 mg Frequency: once daily Duration: 12 weeks Note: Should be used in combination with Peginterferon alfa and Ribavirin. Taken with or without food. A dose recommendation cannot be made for patients with severe renal impairment or end stage renal disease. |
|
Indication: Chronic Hepatitis C Age: Adult Condition: Genotype 2 (HCV Mono-infected and HCV/HIV-1 Co-infected) |
Dose: Tablet – 400 mg Frequency: once daily Duration: 12 weeks Note: Should be used in combination with Ribavirin. Taken with or without food. A dose recommendation cannot be made for patients with severe renal impairment or end stage renal disease. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Tablet – No approved pediatric dosage available Note: No approved pediatric dosage available |
Administration
- Take with food
- Take at same time daily
Side Effect
- Fatigue (38%)
- Headache (24%)
- Nausea (22%)
- Insomnia (15%)
- Pruritus (11%)
- Sofosbuvir plus ribavarin (24 weeks)
- Fatigue (30%)
- Headache (30%)
- Nausea (13%)
- Insomnia (16%)
- Pruritus (27%)
- Asthenia (21%)
- Diarrhea (12%)
- Fatigue (59%)
- Headache (36%)
- Nausea (34%)
- Insomnia (25%)
- Pruritus (17%)
- Anemia (21%)
- Rash (18%)
- Decreased appetite (18%)
- Chills (17%)
- Influenza-like illness (16%)
- Pyrexia (18%)
- Diarrhea (12%)
- Neutropenia (17%)
- Myalgia (14%)
- Irritability (13%)
- Fatigue (55%)
- Headache (44%)
- Nausea (29%)
- Insomnia (29%)
- Pruritus (17%)
- Anemia (12%)
- Rash (18%)
- Decreased appetite (18%)
- Chills (18%)
- Influenza-like illness (18%)
- Pyrexia (14%)
- Diarrhea (17%)
- Neutropenia (12%)
- Myalgia (16%)
- Irritability (16%)
- Anemia (10%)
- Asthenia (6%)
- Rash (8%)
- Decreased appetite (6%)
- Chills (2%)
- Influenza-like sickness (3%)
- Pyrexia (4%)
- Diarrhea (9%)
- Myalgia (6%)
- Irritability (10%)
- Anemia (6%)
- Rash (9%)
- Decreased appetite (6%)
- Chills (2%)
- Influenza-like sickness (6%)
- Pyrexia (4%)
- Myalgia (9%)
- Irritability (10%)
- Neutropenia
- Pancytopenia
- Severe depression (particularly in patients with pre-existing psychiatric illness)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Rifampicin, St. John's wort, carbamazepine, phenytoin, modafinil, phenobarbital/oxcarbazepine, rifabutin/rifapentine
|
Reduced therapeutic effect
|
|
P-gp and/or BCRP inhibitors
|
Interaction mentioned but specific effect not detailed
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Pregnancy
|
Risk of birth defects with combination therapy
|
|
Potential Pregnancy
|
Risk to unborn child
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep out of the reach of children. Keep in a cool & dry place. Protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.