Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: Adult |
Dose: Oral – 5 mg Frequency: once daily Note: May increase dose at intervals of 2 weeks if needed. Maximum: 40 mg once daily. |
|
Indication: Hypertension Age: Elderly Condition: greater than 65 years |
Dose: Oral – 2.5 mg Frequency: once daily Note: Increased to 5 mg once daily if required. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: No approved pediatric dosage available Note: Not recommended |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: Creatinine Clearance less than 30 mL/min |
Dose: Tablet – 2.5 mg Frequency: once daily Note: Initial dose |
|
Condition: Renal impairment: Creatinine Clearance less than 30 mL/min |
Dose: Tablet – 5 mg Frequency: once daily Note: Maintenance dose; increased to 5 mg if required |
Administration
- May be taken with or without food
- Take at same time each day
Side Effect
- Headache (6-9%)
- Fatigue (2-5%)
- Dizziness (2-4%)
- Diarrhea (2-3%)
- Nausea (1-3%)
- Increased triglyceride levels and insulin resistance
- decreased high-density lipoprotein (HDL) levels (1%)
- Insomnia (1%)
- Peripheral edema (1%)
- Weakness (1%)
- Bradycardia
- Chest pain
- Dyspnea
- Anaphylaxis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Paroxetine, Fluoxetine, Propafenone, Thioridazine, Quinidine
|
Increased plasma concentrations
|
|
Amiodarone, Disopyramide, Diltiazem, Verapamil
|
May cause conduction disturbance
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hepatic Impairment
|
Drug metabolism is affected, increasing risk of side effects
|
|
Sick Sinus Syndrome, Heart Block
|
Can worsen heart rhythm abnormalities
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.