Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Rheumatoid Arthritis Age: Adult |
Dose: Oral – 50 mg Frequency: 8-12 hourly |
|
Indication: Osteoarthritis Age: Adult |
Dose: Oral – 50 mg Frequency: 8-12 hourly |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Acute pain, inflammation and swelling Age: Child 14 years or over |
Dose: Oral – 75 to 100 mg daily Frequency: Two to three divided doses Note: Maximum Dose: 150 mg daily |
|
Indication: Postoperative pain or fever in ear, nose, or throat infection Age: Child 9 to 13 years |
Dose: Oral – Up to 2 mg/kg daily Frequency: Three divided doses Note: Maximum Dose: 100 mg daily |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Not mentioned Note: Patients with renal impairment had area under the plasma concentration–time curve values and elimination rates that were comparable to healthy patients |
Administration
- Take with food
- Take immediately after meals
Side Effect
- gastrointestinal discomfort
- epigastria pain
- eructation
- nausea and Diarrhoea
- headache and bleeding sometime may occur
- Occasionally skin rash
- peripheral oedema and abnormalities of serum transaminase have been reported
- Very rarely reported side effects include activation of peptic ulcer
- haematemesis or melena
- blood dyscrasia (extensive usage)
- There have been isolated reports of anaphylactoid reactions
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Methotrexate
|
May increase serum levels
|
|
Other NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac), Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban) (e.g. warfarin)
|
Higher risk of GI bleeding
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Active Peptic Ulcer
|
Risk of bleeding
|
|
Asthma
|
Can trigger asthma attack
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.