Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Adults |
Dose: Tablet – 500 or 875 mg Frequency: every 12 hours Note: Based on the amoxicillin component. |
|
Age: Adults |
Dose: Tablet – 250 or 500 mg Frequency: every 8 hours Note: Based on the amoxicillin component. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Tablet – 500 or 875 mg Frequency: every 12 hours Note: based on the amoxicillin component |
|
Age: Pediatric |
Dose: Tablet – 250 or 500 mg Frequency: every 8 hours Note: based on the amoxicillin component |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment with Creatinine Clearance less than 30 mL/minute |
Dose: Tablet – 875 mg / 125 mg or Extended-release tablets Note: Do not use 875 mg / 125 mg tablet or extended-release tablets |
|
Condition: Renal impairment with Creatinine Clearance 10-30 mL/minute |
Dose: Tablet – 250-500 mg / 125 mg Frequency: every 12 hours Note: administered by mouth |
Administration
- Take with food
- Take at start of meal
Side Effect
- Diarrhea (3-34% varies upon dose and regimen)
- Diaper rash (3.5%)
- Mycosis (3.3%)
- Nausea (2-3%)
- Rash (1-3%)
- Vomiting (1-2.2%)
- Loose stool (1.6%)
- Candidiasis (1.4%)
- Vaginitis (1%)
- Hypersensitivity reactions
- Anaphylaxis
- Anemia
- Thrombocytopenia
- Leukopenia
- Agranulocytosis
- Hepatoxicity
- AST/ALT elevation
- Pseudomembranous colitis
- Serum sickness
- Abdominal discomfort
- Cholestatic jaundice
- Flatulence
- Anaphylactic reaction with CV collapse esp with parenteral use
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Allopurinol
|
May reduce renal tubular secretion of amoxicillin
|
|
Oral contraceptives
|
May reduce efficacy
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
This should be stored below 25°C, protected from light and moisture. Once reconstituted suspension should be kept in the refrigerator (but not frozen) and should be usedby 7 days. Once reconstituted vial must be used within 20 minutes.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.