Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Acute Exacerbation of Chronic Bronchitis Age: Adult |
Dose: Oral – 250-500 mg Frequency: every 12 hours Duration: 7-14 days Note: administered by mouth |
|
Indication: Acute Exacerbation of Chronic Bronchitis Age: Adult Condition: Extended release |
Dose: Oral – 1000 mg Frequency: once daily Duration: 7 days Note: administered by mouth |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Otitis Media Age: less than 6 months |
Dose: Oral – 15 mg/kg/day Note: Safety and efficacy not established |
|
Indication: Otitis Media Age: greater than 6 months |
Dose: Oral – 15 mg/kg/day Frequency: divided every 12 hours Duration: 10 days Note: by mouth (oral); not to exceed 500 mg/dose; because of increased resistance to S Pneumoniae and H Influenzae, not routinely recommended as treatment option |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Adult Condition: Renal impairment Moderate CrCl 30-60 mL/min |
Dose: Tablet – Dosage adjustment not necessary Note: No dosage adjustment necessary |
|
Age: Adult Condition: Renal impairment Moderate CrCl 30-60 mL/min and concomitant atazanavir or ritonavir-containing regimens |
Dose: Tablet – Decrease clarithromycin dose by 50% Note: Decrease clarithromycin dose by 50% |
Administration
- Standard tablets: Can be taken with or without food
- XL tablets: Take with food
Side Effect
- Gastrointestinal (GI) effects
- Abnormal taste (adults
- 3-7%)
- Diarrhea (3-6%)
- Nausea (adults
- 3-6%)
- Vomiting (adults
- 1%, children
- 6%)
- Elevated blood urea nitrogen (BUN, 4%)
- Abdominal pain (adults 2%, children 3%)
- Rash (children 3%)
- Dyspepsia (2%)
- Heartburn (adults 2%)
- Headache (2%)
- Elevated prothrombin time (PT, 1%)
- Anaphylaxis
- Anorexia
- Anxiety
- Clostridium difficile colitis
- Dizziness
- Dyspnea
- Elevated liver function tests
- Glossitis
- Hallucinations
- Hepatic dysfunction
- Hepatitis
- Hypoglycemia
- Increased alkaline phosphatase
- Increased aspartate aminotransferase
- Increased bilirubin
- Increased serum creatinineeatinine
- Jaundice
- Leukopenia
- Manic behavior
- Neuromuscular blockade
- Neutropenia
- Pancreatitis
- Psychosis
- QT prolongation
- Seizures
- Stevens-Johnson syndrome
- Thrombocytopenia
- Pseudomembranous colitis
- anaphylaxis
- Stevens-Johnson syndrome
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
CYP3A inducers (e.g. phenytoin, carbamazepine, dexamethasone)
|
Reduced efficacy
|
|
Ritonavir
|
Inhibition of metabolism
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Patients Receiving Terfenadine
|
Risk of cardiac arrhythmias
|
|
Patients Receiving Astemizole
|
Risk of fatal arrhythmias
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place, protected from light & moisture. The reconstituted suspension must be used within 7 days if kept at room temperature and within 14 days when stored in a refrigerator. Keep out of reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.