Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Status epilepticus Condition: Loading Dose |
Dose: Intravenous – 10-15 mg/kg or 15-20 mg/kg at 25-50 mg/min Note: Administer intravenous slowly; not to exceed 50 mg/min |
|
Indication: Status epilepticus Condition: Maintenance |
Dose: Intravenous – 100 mg Frequency: every 6-8 hours as needed Note: Administer intravenous slowly; not to exceed 50 mg/min |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Status Epilepticus Condition: Loading dose |
Dose: Intravenous – 15-20 mg/kg Frequency: single or divided dose Note: if necessary may administer additional dose of 5-10 mg/kg 10 minutes after loading dose |
|
Indication: Status Epilepticus Condition: Maintenance |
Dose: Intravenous – 4-8 mg/kg/day Frequency: divided twice daily |
Administration
- For IV/IM use only
- Give slowly (max 50mg/min)
Side Effect
- Hypersensitivity
- lack of appetite
- headache
- dizziness
- tremor
- transient nervousness
- insomnia
- GI disturbances (eg nausea
- vomiting
- constipation)
- tenderness and hyperplasia of the gums
- acne
- hirsutism
- coarsening of the facial features
- rashes
- osteomalacia
- Phenytoin toxicity as manifested as a syndrome of cerebellar
- vestibular
- ocular effects
- notably nystagmus
- diplopia
- slurred speech
- and ataxia
- also with mental confusion
- dyskinesias
- exacerbations of seizure frequency
- hyperglycaemia
- Solutions for Injection may cause local irritation or phlebitis
- Prolonged use may produce subtle effects on mental function and cognition
- especially in children
- Toxic epidermal necrolysis
- Stevens-Johnson syndrome
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Other sedative drugs, Ethanol
|
Effects may be potentiated
|
|
Paracetamol, Lithium
|
Enhances toxic effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Sinus Bradycardia (IV)
|
Risk of cardiac conduction problems
|
|
Heart Block (IV)
|
Can worsen cardiac conduction
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Intravenous: Store at room temperature of 15-30°C.
Oral:
Tablet/capsule: Store below 30°C. Protect from light and moisture;
Oral suspension: Store at room temperature of 20-25°C, do not freeze, protect from light.
Oral:
Tablet/capsule: Store below 30°C. Protect from light and moisture;
Oral suspension: Store at room temperature of 20-25°C, do not freeze, protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.