Medicine Overview

Indication

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Adult Dose

Clinical InformationAdministration Information
Indication: Advanced renal cell carcinoma
Age: Adult
Dose: Oral – 400 mg
Frequency: twice daily
Note: May continue until patient is no longer responding or unacceptable toxicity occurs. Dose adjustment not necessary for mild to moderate hepatic impairment. Severe hepatic impairment not studied.
Indication: Hepatocellular Carcinoma
Age: Adult
Dose: Oral – 400 mg
Frequency: twice daily
Note: May continue until patient is no longer responding or unacceptable toxicity occurs. Dose adjustment not necessary for mild to moderate hepatic impairment. Severe hepatic impairment not studied.

Child Dose

Clinical InformationAdministration Information
Age: Child
Dose: Safety and efficacy not established
Note: Not recommended

Renal Dose

Clinical InformationAdministration Information
Condition: Mild to moderate renal impairment
Dose: Not specified
Note: Dose adjustment not necessary
Condition: Severe renal impairment
Dose: Not specified
Note: Not studied
Administration
  • Take on empty stomach
  • Take 1 hour before or 2 hours after meals
Side Effect

Drug Interaction

Drug NameRisk Factors
Carbamazepine, Dexamethasone, Phenobarbital, Phenytoin, Rifampicin
May decrease sorafenib plasma concentration
Doxorubicin, Irinotecan
May increase plasma concentration of these drugs

Disease Interaction

Disease NameRisk Factors
No specific contraindications listed
Monitor for general reactions

Pregnancy

Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 25° C.

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.