Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Dermatitis Herpetiformis Age: Adult |
Dose: Oral – 50 mg Frequency: once daily Note: Titrate to 300 mg once daily or higher to achieve the desired effect. Reduce dose to the minimum effective dose within the range of 50-300 mg once daily as soon as possible. |
|
Indication: Leprosy Age: Adult |
Dose: Oral – 100 mg Frequency: once daily Note: In combination with other antileprosy drugs. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Leprosy Age: Child |
Dose: Oral – 1-2 mg/kg Frequency: once daily Note: not to exceed 100 mg/day in combination with other antileprosy agents |
|
Indication: Leprosy Age: Child |
Dose: Oral – 2 mg/kg Frequency: once daily Note: maximum 100 mg |
Administration
- Can be taken with or without food
- Take regularly
Side Effect
- Hemolysis
- Methemoglobinemia
- Reactional states (ie abrupt changes in clinical activity occurring during any leprosy treatment, classified as reversal of erythema nodosum leprosum reactions)
- Insomnia
- Headache
- Exfoliative dermatitis
- Photosensitivity
- Nausea
- Vomiting
- Anemia
- Leukopenia
- Agranulocytosis
- Hepatitis
- Cholestatic jaundice
- Peripheral neuropathy (usually in nonleprosy patients)
- Blurred vision
- Tinnitus
- SLE
- Agranulocytosis
- serious cutaneous hypersensitivity reactions
- exfoliative dermatitis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Rifampicin
|
Decreased serum concentration of dapsone
|
|
Probenecid, Trimethoprim
|
Increased plasma concentration
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Anaemia
|
Can worsen anemia condition
|
|
Porphyria
|
Can trigger acute attacks
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Tablet: Store between 15-30°C. Protect from light. Topical Gel: Store between 20-25°C. Do not freeze.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.