Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Premature Ejaculation Age: Adult: 18-64 years |
Dose: Oral – 30 mg Frequency: approximately 1-3 hours before sexual activity Note: Subsequent doses adjusted according to response. Maximum: 60 mg. The dose should not be taken more than once in 24 hours. Review treatment after 4 weeks (6 doses) and at least 6 months thereafter. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Tablet – No approved pediatric dosage available Note: Not recommended |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Mild or moderate renal impairment |
Dose: Tablet – No dose adjustment required Note: Caution is advised. Use with caution if eGFR 30–80 mL/minute/1.73m2. |
|
Condition: Severe renal impairment |
Dose: Tablet – Not recommended Note: Avoid if eGFR less than 30 mL/minute/1.73m2. |
Administration
- Can be taken with or without food
- Take with full glass of water
Side Effect
- Syncope characterized as loss of consciousness has been reported
- The majority of cases occurred during the first 3 hrs after dosing, after the 1st dose or associated with study-related procedures in the clinic setting (eg blood draw and orthostatic maneuvers and blood pressure measurements)
- Prodromal symptoms often preceded the syncope
- Orthostatic hypotension has been reported in clinical trials
- headache
- dizziness
- nausea
- diarrhea
- insomnia and fatigue
- The most common events leading to discontinuation were nausea and dizziness
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Monoamine oxidase inhibitors
|
Potential serious reactions
|
|
Thioridazine
|
Inhibits metabolism
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Significant Cardiac Conditions
|
Risk of cardiovascular events
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.