Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Moderate to severe pain Age: Adult |
Dose: Tablet – 1-2 tablet Frequency: every 6 hours Duration: Maximum duration: 5 days Note: Maximum: 8 tablets/day. |
|
Indication: Moderate to severe pain Age: Adult Condition: Moderate hepatic impairment |
Dose: Tablet – 1-2 tablet Frequency: Increased dosing interval Note: General adult dose is 1-2 tablets every 6 hours with a maximum of 8 tablets/day and maximum duration of 5 days. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Tablet – No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: Creatinine Clearance 10-30 mL/min |
Dose: Not specified Frequency: every 12 hours Note: Increase dosing interval to 12 hourly. |
|
Condition: Renal impairment: Creatinine Clearance less than 10 mL/min |
Dose: Not specified Note: Not recommended. |
Administration
- May be taken with or without food
- Take with full glass of water
Side Effect
- Postural hypotension
- resp depression
- hepatotoxicity
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
- bradycardia
- collapse
- allergic reactions w/ resp symptoms (eg dyspnoea, bronchospasm, wheezing, angioneurotic oedema)
- changes in appetite
- motor weakness
- changes in mood
- activity
- cognitive and sensorial capacity
- exacerbation of asthma
- withdrawal symptoms (eg agitation, anxiety)
- skin rash
- blood dyscrasias
- hypoprothrombinemia
- Severe anaphylactic reactions
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
SSRIs, SNRIs, TCAs, 5-HT agonists
|
Increased risk of seizures and serotonin syndrome
|
|
Barbiturates, Benzodiazepines (Diazepam, Alprazolam, Lorazepam, Clonazepam, Midazolam), Anxiolytics, Hypnotics, Sedative Antidepressants (Fluoxetine, Sertraline, Paroxetine, Citalopram, Escitalopram, Venlafaxine, Duloxetine), Sedative Antihistamines (Diphenhydramine, Loratadine, Levocetirizine, Cetirizine, Fexofenadine, Hydroxyzine, Bilastin), Neuroleptics, Centrally-acting antihypertensive drugs, Thalidomide, Baclofen
|
Increased CNS depression
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Acute Alcohol Intoxication
|
Risk of liver toxicity
|
|
Severe Hepatic Impairment
|
Increased risk of toxicity
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place. Do not freeze. Keep all medicines out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.