Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypercholesterolemia Age: Adult |
Dose: Oral – 2 mg Frequency: once daily Note: May increase to 4 mg every day if necessary |
|
Indication: Hypercholesterolemia Age: Adult Condition: Hepatic Impairment |
Dose: Oral Note: Contraindicated in active liver disease or unexplained transaminase elevations |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Tablet – Safety and efficacy not established Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Moderate to severe renal impairment (CrCl 15-60 mL/min, not on haemodialysis) |
Dose: Initial dose – 1 mg Frequency: once daily Note: Max: 2 mg once daily |
|
Condition: End-stage renal disease (on haemodialysis) |
Dose: Initial dose – 1 mg Frequency: once daily Note: Max: 2 mg once daily |
Administration
- May be taken with or without food
- Take at same time daily
Side Effect
- Liver enzyme abnormalities
- myalgia
- muscle spasm
- back pain
- diarrhoea
- constipation
- pain in extremities
- arthralgia
- headache
- dizziness
- influenza
- nasopharyngitis
- abdominal discomfort
- abdominal pain
- dyspepsia
- nausea
- asthenia
- malaise
- fatigue
- hepatitis
- jaundice
- hypoaesthesia
- insomnia
- depression
- interstitial lung disease
- erectile dysfunction
- cognitive impairment (eg memory loss and impairment, confusion, forgetfulness, amnesia)
- Myopathy and rhabdomyolysis w/ acute renal failure secondary to myoglobinuria
- hepatic failure
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Erythromycin, rifampicin
|
Increased bioavailability
|
|
Gemfibrozil, colchicine, niacin, other fibrates
|
Increased risk of myopathy/rhabdomyolysis
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Active Liver Disease
|
Can worsen liver function
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place, protect from light & moisture . Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.