Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Chronic Hepatitis C Genotype 1 Condition: Without cirrhosis or with compensated (Child-Pugh A) cirrhosis |
Dose: Oral – 60 mg (plus sofosbuvir 400 mg) Frequency: once daily Duration: 12 weeks |
|
Indication: Chronic Hepatitis C Genotype 1 Condition: Decompensated (Child-Pugh B or C) cirrhosis or posttransplant |
Dose: Oral – 60 mg (plus sofosbuvir 400 mg) Frequency: once daily Duration: 12 weeks Note: plus ribavirin |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: less than 18 years |
Dose: Not established Note: Safety and effectiveness in pediatric patients under 18 years of age have not been established. |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment (any degree) |
Dose: No dose adjustment required Note: Renal impairment (any degree): No dose adjustment required |
Administration
- Can take with or without food
- Take at same time daily
Side Effect
- Headache (14%)
- Fatigue (14%)
- Nausea (8%)
- Diarrhea (5%)
- Elevated lipase
- More than 3 x ULN (2%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Phenytoin, carbamazepine, oxcarbazepine, phenobarbital, rifampicin, rifabutin, rifapentine, systemic dexamethasone, St. John's wort
|
May lead to lower exposure & loss of efficacy
|
|
Strong or moderate CYP3A4 & P-gp inducers
|
Decreased plasma levels & therapeutic effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Drug Hypersensitivity
|
Risk of allergic reaction
|
|
Strong CYP3A4 Inducers Use
|
Risk of treatment failure
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at room temperature below 30°C, protect from light. keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.