Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Dissolution of cholesterol-rich gallstones Age: Adult |
Dose: Oral – 8-12 mg/kg Frequency: once daily at bedtime or in 2 divided doses Duration: continued for 3-4 months after radiological disappearance of gallstones. Up to 2 years. |
|
Indication: Dissolution of cholesterol-rich gallstones Age: Adult Condition: Obese patients |
Dose: Oral – Up to 15 mg/kg Frequency: daily Duration: Up to 2 years. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Neonatal cholestasis associated with parenteral nutrition, biliary atresia and cystic fibrosis Age: Neonate |
Dose: Oral, OGT, or NGT – 10 to 15 mg/kg Frequency: Every 12 hours Note: by mouth (oral), orogastric tube, or nasogastric tube |
Administration
- Should be taken with food
- Take at same time each day
Side Effect
- Headache
- Dizziness
- Diarrhea
- Dyspepsia
- Nausea/vomiting
- Back pain
- Upper respiratory tract infection (URTI)
- Alopecia
- Rash
- Hyperglycemia
- Flatulence
- Peptic ulcer
- Urinary Tract Infection (UTI)
- Leukopenia
- Thrombocytopenia
- Cholecystitis
- Fatigue
- Abdominal pain
- Thrombocytopenia
- Pruritus
- Angioedema
- Peripheral edema
- Biliary pain
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Cholestyramine, charcoal, antacids
|
May reduce effectiveness
|
|
Aluminum-based antacids
|
May reduce absorption
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Acute Inflammation of Gallbladder, Biliary Tract
|
May worsen condition
|
|
Occlusion of Biliary Tract
|
Treatment will be ineffective
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store below 25° C. Protected from light and moisture. Keep the medicine out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.