Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Spasticity Age: Adult |
Dose: Oral – Initially, 25 mg Frequency: daily Duration: increased gradually at 7-day intervals over 7 weeks Note: Discontinue if no response after 45 days of treatment. Max: 100 mg 4 times daily. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Spasticity Age: Child |
Dose: Oral – Initially, 0.5 mg/kg Frequency: once daily Note: may increase gradually to 2 mg/kg 3-4 times daily; Maximum: 100 mg 4 times daily |
Administration
- Can take with or without food
- Take at regular intervals
Side Effect
- Fatigue
- muscle weakness/pain
- GI disturbances
- CNS effects
- tachycardia
- unstable BP
- dyspnoea
- drowsiness
- rashes
- pruritus
- chills and fever
- visual disturbances
- dysphagia
- speech disturbances
- haematuria
- crystalluria
- urinary frequency
- retention and incontinence
- Increased serum AST (SGOT)
- ALT (SGPT)
- alkaline phosphatase
- LDH
- BUN
- and total serum bilirubin concentrations
- Difficult erection
- Abnormal hair growth
- Aplastic anemia
- Anemia
- Leukopenia
- Lymphoma
- Thrombocytopenia
- Hepatotoxicity
- pleural effusion with pericarditis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
CNS depressants
|
CNS effects enhanced
|
|
Oestrogens, calcium-channel blockers
|
Interactions mentioned but specific effects not detailed
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Active Liver Disease
|
Risk of liver toxicity
|
|
Acute Muscle Spasm
|
Not effective for acute spasms
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool & dry place, protected from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.