Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: General bacterial infections Age: Adult |
Dose: Intramuscular Injection – 0.3 to 1.2 million units up to 2.4 million units Frequency: Repeated every five to seven days Note: As a single dose |
|
Indication: Group-A beta-hemolytic streptococcal infections Age: Adult |
Dose: Intramuscular Injection – 1.2 million units Frequency: Once Note: A single dose |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Congenital syphilis Age: Infants Condition: Asymptomatic infants with normal cerebrospinal fluid |
Dose: Intramuscular Injection – 50,000 units per kg Frequency: single dose |
|
Indication: Streptococcal infection Age: Children |
Dose: Intramuscular Injection – 0.3 million to 0.9 million units Note: According to body weight |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment with Creatinine Clearance 10-50 mL/minute |
Dose: Decrease dose by 25% |
|
Condition: Renal Impairment with Creatinine Clearance less than 10 mL/minute Condition: Hemodialysis |
Dose: Decrease dose by 50-70% Dose: Removed by hemodialysis Note: Administer after dialysis |
Administration
- Given by injection only
- Professional use only
Side Effect
- Hypersensitivity reactions
- uticaria
- fever
- joint pains
- rashes
- angioedema
- serum sickness-like reactions
- haemolytic anaemia
- interstitial nephritis
- neutropenia
- thrombocytopenia
- CNS toxicity including convulsions
- diarrhoea
- antibiotic-associated colitis
- Anaphylaxis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Probenecid
|
Prolongs T1/2 of benzathine benzylpenicillin
|
|
Chloramphenicol, Tetracyclines, Other antibacterials
|
Bacteriostatic drugs may interfere
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 2-8°C. Do not freeze.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.