Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Anxiety; Depression; Obsessive compulsive disorder Age: Adult |
Dose: Oral – 10 mg Frequency: once daily Note: Increased after at least a week if needed. Maximum: 20 mg once daily. |
|
Indication: Panic disorder with or without agoraphobia Age: Adult |
Dose: Oral – Initially, 5 mg Frequency: once daily Note: Increased after a week to 10 mg once daily. Maximum: 20 mg daily. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Major Depressive Disorder Age: less than 12 years |
Dose: PO – Note: Safety and efficacy not established |
|
Indication: Major Depressive Disorder Age: greater than 12 years |
Dose: PO – 10 mg Frequency: once daily Note: may increase dose after at least 3 weeks; not to exceed 20 mg/day; by mouth (oral) |
Administration
- Take with or without food
- Take once daily
Side Effect
- Headache (24%)
- Nausea (18%)
- Ejaculation disorder (9-14%)
- Somnolence (4-13%)
- Insomnia (7-12%)
- Xerostomia (4-9%)
- Constipation (3-6%)
- Fatigue (2-8%)
- Libido decrease (3-7%)
- Anorgasmia (2-6%)
- Flatulence (2%)
- Toothache (2%)
- Weight gain (1%)
- Menstrual disorder (2%)
- Neck/shoulder pain (3%)
- Rhinitis (5%)
- Flu-like syndrome (5%)
- Ejaculation disorder (9-14%)
- Arthralgia
- Abdominal pain
- Abnormal bleeding
- Abnormal dreams
- Allergy
- Blurred vision
- Bronchitis
- Chest pain
- Constipation
- Decreased appetite
- Decreased concentration
- Disrupts platelets/hemostasis
- Dizziness
- Dyspepsia
- Fever
- Heartburn
- Hot flashes
- Impotence
- Irritability
- Jaw stiffness
- Lethargy
- Lightheadedness
- Menstrual disorder
- Hypertension
- Palpitations
- Migraine
- Myalgia
- Paresthesia
- Rash
- Sweating
- Tinnitus
- Tremor
- Urinary frequency
- Urinary Tract Infection (UTI)
- Vertigo
- Vomiting
- Yawning
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Aspirin, NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac), Drugs that affect coagulation
|
Increased risk of bleeding
|
|
CYP2C19 inducers (e.g. carbamazepine, rifampin, phenytoin), CYP3A4 inducers (e.g. nafcillin, nevirapine)
|
Serum levels may be reduced
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store below 30°C temperature and protect from light & moisture. Keep the medicine out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.