Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Intra-abdominal infections Age: Adult |
Dose: Intravenous Injection – 1 g Frequency: every 8 hours Note: Administered via intravenous injection over approximately 3-5 minutes or infused over approximately 15-30 minutes. |
|
Indication: Skin and skin structure infections Age: Adult |
Dose: Intravenous Injection – 500 mg Frequency: every 8 hours Note: Administered via intravenous injection over approximately 3-5 minutes or infused over approximately 15-30 minutes. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Children |
Dose: Intravenous – 60 mg/kg/day Frequency: every 8 hours Note: maximum 3 g/day |
|
Indication: Meningitis Age: Children |
Dose: Intravenous – 120 mg/kg/day Frequency: every 8 hours Note: maximum 6 g/day |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment with Creatinine Clearance 26-50 ml/min |
Dose: Form not specified – Usual dose Frequency: every 12 hours |
|
Condition: Renal impairment with Creatinine Clearance 10-25 ml/min |
Dose: Form not specified – Half the usual dose Frequency: every 12 hours |
Administration
- For IV administration only
- Give as infusion over 15-30 minutes
Side Effect
- Constipation (1-7%)
- Diarrhea (4-5%)
- Nausea or vomiting (1-4%)
- Rash (2-3%
- includes diaper-area moniliasis in pediatric patients)
- Headache (2%)
- Inflammation at injection site (2%)
- Sepsis (2%)
- Oral moniliasis (≤2% in pediatric patients)
- Bleeding (1.2%)
- Apnea (1%)
- Constipation (1%)
- Glossitis (1%)
- Injection-site reaction (1%)
- Phlebitis or thrombophlebitis (1%)
- Pruritus (1%)
- Septic shock (1%)
- Agranulocytosis
- Angioedema
- Erythema multiforme
- Hypersensitivity reaction
- Hypokalemia
- Leukopenia
- Neutropenia
- Pleural effusion
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis disorders or renal impairment
- Anaphylaxis
- pseudomembranous colitis
- Stevens-Johnsons sydrome
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Probenecid
|
Increased plasma concentration
|
|
Valproic acid
|
May decrease plasma levels, increasing risk of seizures
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hypersensitivity to Meropenem/Carbapenems
|
Risk of severe allergic reactions
|
|
History of Anaphylactic Reaction to β-Lactams
|
Risk of anaphylaxis
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Vial store in a cool, dry place (below 30oC), away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.