Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Adjunct to diet and exercise to improve glycemic control Age: Adults greater than 18 years Condition: Type 2 diabetes mellitus |
Dose: Oral Tablet – 100 mg Frequency: once daily Note: Taken before the first meal of the day. |
|
Indication: Reduce the risk of major adverse cardiovascular events Age: Adults greater than 18 years Condition: Type 2 diabetes mellitus and established cardiovascular disease |
Dose: Oral Tablet – 100 mg Frequency: once daily Note: Taken before the first meal of the day. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Safety and efficacy not established Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment eGFR greater than 60 mL/min/1.73 m2 |
Dose: Not specified – Not specified Note: No dosage adjustment necessary |
|
Condition: Renal impairment eGFR 30 to less than 60 mL/min/1.73 m2 |
Dose: Not specified – 100 mg Frequency: once daily |
Administration
- Take before first meal
- Take at same time daily
Side Effect
- Female genital mycotic infections (10.4-11.4%)
- Increased urination (4.6-5.3%)
- Male genital mycotic infections (3.7-4.2%)
- Vulvovaginal pruritus (1.6-3%)
- Thirst (2.3-2.8%)
- Constipation (1.8-2.3%)
- Nausea (2.2-2.3%)
- Abdominal pain (1.7-1.8%)
- Overall population (2.3-3.4%)
- Age More than 75 yr (4.9-8.7%)
- eGFR Less than 60/mL/min/1.73 m³ (4.7-8.1%)
- Use of loop diuretic (3.2-8.8%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Rifampicin
|
Decreased efficacy
|
|
Digoxin
|
Increase AUC & Cmax (not clinically meaningful)
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Drug Hypersensitivity
|
Risk of allergic reaction
|
|
Severe Renal Impairment
|
Risk of treatment failure
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep in a dry place away from light and heat. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.